Relationship between sensorimotor peripheral nerve function and indicators of cardiovascular autonomic function in older adults from the Health, Aging and Body Composition Study
Relationship between sensorimotor peripheral nerve function and indicators of cardiovascular autonomic function in older adults from the Health, Aging and Body Composition Study
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DOI：
10.1016/j.exger.2017.04.007
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发表时间：
2017-10-01
影响因子：
3.9
通讯作者：
Strotmeyer, Elsa S.
中科院分区：
文献类型：
--
作者：
Lange-Maia, Brittney S.;Newman, Anne B.;Strotmeyer, Elsa S.
背景：年龄相关的周围神经系统(PNS)损害在老年人中非常普遍。虽然糖尿病患者的感觉运动和心血管自主神经功能已被证明是相关的，但在一般社区居住的老年人群中，这种关系的性质尚不清楚。方法：在2000/01年的门诊中，2399名健康、老龄化和身体成分的参与者(n=2399，年龄=76.5+/-2.9岁，52%的女性，38%的黑人)接受了周围神经测试。测量腓骨运动神经的神经传导幅度和速度。用振动检测阈值和拇趾单丝(1.4-g/10-g)测试评价感觉神经功能。心血管自主神经功能指标包括体位性低血压、静息心率(HR)以及次极量运动试验(400m步行)后的HR反应和恢复情况。结果：在完全调整的模型中，较差的运动神经传导速度(
Background: Age-related peripheral nervous system (PNS) impairments are highly prevalent in older adults. Although sensorimotor and cardiovascular autonomic function have been shown to be related in persons with diabetes, the nature of the relationship in general community-dwelling older adult populations is unknown.Methods: Health, Aging and Body Composition participants (n = 2399, age = 76.5 +/- 2.9 years, 52% women, 38% black) underwent peripheral nerve testing at the 2000/01 clinic visit. Nerve conduction amplitude and velocity were measured at the peroneal motor nerve. Sensory nerve function was assessed with vibration detection threshold and monofilament (1.4-g/10-g) testing at the big toe. Symptoms of lower-extremity peripheral neuropathy were collected by self-report Cardiovascular autonomic function indicators included postural hypotension, resting heart rate (HR), as well as HR response to and recovery from submaximal exercise testing (400 m walk). Multivariable modeling adjusted for demographic/lifestyle factors, medication use and comorbid conditions.Results: In fully adjusted models, poor motor nerve conduction velocity (