Overview of the mechanisms of gastroesophageal reflux
Overview of the mechanisms of gastroesophageal reflux
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DOI：
10.1016/s0002-9343(01)00828-2
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发表时间：
2001-12-03
影响因子：
5.9
通讯作者：
Orlando, RC
中科院分区：
文献类型：
--
作者：
Orlando, RC
几乎每天都会发生酸性胃内容物通过食管胃交界处反流到食管腔。食管胃交界处由几个结构组成，有助于其作为主要抗反流屏障的功能。只有当一个或多个这些组件失败时，才会发生反流性食管炎。本综述的最初重点是短暂的下食管括约肌松弛，迷走神经介导的反射弧，占几乎所有的反流事件在健康个体和大多数反流事件在反流性食管炎。糜烂性食管炎与食管下括约肌（LES）压力低或缺失（功能不全）和食管胃连接处解剖结构破坏（如食管裂孔疝）的相关性也很重要，特别是关于LES功能障碍和疝是糜烂性疾病的原因还是后果。(C)2001年，Excerpta Medica，Inc.
Reflux of acidic gastric contents through the esophagogastric junction into the esophageal lumen occurs in everyone nearly every day. The esophagogastric junction is composed of several structural components that contribute to its function as the primary antireflux barrier. Only when 1 or more of these components fail does reflux esophagitis develop. The initial focus of this review is on transient lower esophageal sphincter relaxations, a vagally mediated reflex arc that accounts for almost all reflux events in healthy individuals and the majority of reflux events in those with reflux esophagitis. The association of erosive esophagitis with low or absent (incompetent) lower esophageal sphincter (LES) pressure and anatomic disruptions of the esophagogastric junction, such as hiatal hernia, are also important, especially with respect to whether the LES dysfunction and hernia are the cause or the consequence of erosive disease. (C) 2001 by Excerpta Medica, Inc.