Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure
Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure
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DOI：
10.1161/01.cir.0000065226.24159.e9
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发表时间：
2003-04-22
期刊：
影响因子：
37.8
通讯作者：
Hill, MRS
中科院分区：
文献类型：
--
作者：
Sutton, MGS;Plappert, T;Hill, MRS
背景-心脏再同步化治疗(CRT)最近已成为治疗中重度收缩性心力衰竭和心室不同步的有效方法。本研究的目的是确定左心室(LV)大小和功能的改善是否与CRT有关。方法和结果-在多中心InSync随机临床评估(MERORIC)试验中，323名患者在基线以及治疗后3个月和6个月获得多普勒超声心动图。其中，172名患者随机接受CRT治疗，151名患者随机接受CRT治疗。测量左心室舒张末和收缩末期容量、射血分数、左心室重量、二尖瓣反流严重程度、二尖瓣充盈早期(E波)和晚期(A波)二尖瓣峰值速度，以及心肌功能指数。在6个月时，CRT与舒张末和收缩末期容量减少相关(均P
Background-Cardiac resynchronization therapy (CRT) has recently emerged as an effective treatment for patients with moderate to severe systolic heart failure and ventricular dyssynchrony. The purpose of the present study was to determine whether improvements in left ventricular (LV) size and function were associated with CRT.Methods and Results-Doppler echocardiograms were obtained at baseline and at 3 and 6 months after therapy in 323 patients enrolled in the Multicenter InSync Randomized Clinical Evaluation (MIRACLE) trial. Of these, 172 patients were randomized to CRT on and 151 patients to CRT off. Measurements were made of LV end-diastolic and end-systolic volumes, ejection fraction, LV mass, severity of mitral regurgitation (MR), peak transmitral velocities during early (E-wave) and late (A-wave) diastolic filling, and the myocardial performance index. At 6 months, CRT was associated with reduced end-diastolic and end-systolic volumes (both P