Hyperdirect insula-basal-ganglia pathway and adult-like maturity of global brain responses predict inhibitory control in children
Hyperdirect insula-basal-ganglia pathway and adult-like maturity of global brain responses predict inhibitory control in children
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DOI：
10.1038/s41467-019-12756-8
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发表时间：
2019-10-22
影响因子：
16.6
通讯作者：
Menon, Vinod
中科院分区：
文献类型：
--
作者：
Cai, Weidong;Duberg, Katherine;Menon, Vinod
抑制性控制是儿童自我调节和认知发展的基础。在这里，我们调查皮质基底神经节通路的抑制控制在儿童和他们的成人样成熟。我们首先进行了全面的荟萃分析现存的神经发育研究的抑制控制和突出的重要差距，在文献中。第二，我们研究了9-12岁儿童在抑制控制过程中皮质基底神经节的激活，并证明了在儿童晚期形成了成人样的抑制控制网络。第三，我们开发了一个神经成熟指数（NMI），它评估儿童和成人之间的大脑激活模式的相似性，并证明，儿童较高的NMI预测更好的抑制控制。第四，我们表明，在丘脑底核的活动和其有效的连接与右前额叶预测儿童的抑制控制。第五，我们在多个队列中复制我们的发现。我们的研究结果提供了深入了解皮层基底神经节电路和全球大脑组织的发展抑制控制。
Inhibitory control is fundamental to children's self-regulation and cognitive development. Here we investigate cortical-basal ganglia pathways underlying inhibitory control in children and their adult-like maturity. We first conduct a comprehensive meta-analysis of extant neurodevelopmental studies of inhibitory control and highlight important gaps in the literature. Second, we examine cortical-basal ganglia activation during inhibitory control in children ages 9-12 and demonstrate the formation of an adult-like inhibitory control network by late childhood. Third, we develop a neural maturation index (NMI), which assesses the similarity of brain activation patterns between children and adults, and demonstrate that higher NMI in children predicts better inhibitory control. Fourth, we show that activity in the subthalamic nucleus and its effective connectivity with the right anterior insula predicts children's inhibitory control. Fifth, we replicate our findings across multiple cohorts. Our findings provide insights into cortical-basal ganglia circuits and global brain organization underlying the development of inhibitory control.