Persistence of skin-resident memory T cells within an epidermal niche
Persistence of skin-resident memory T cells within an epidermal niche
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DOI：
10.1073/pnas.1322292111
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发表时间：
2014-04-08
影响因子：
11.1
通讯作者：
Mueller, Scott N.
中科院分区：
文献类型：
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作者：
Zaid, Ali;Mackay, Laura K.;Mueller, Scott N.
屏障组织如皮肤含有有助于保护免受感染的各种免疫细胞群。这些包括最近鉴定的组织驻留记忆T细胞（T-RM）。在皮肤中，这些记忆性CD 8（+）T细胞在通过感染或炎症被募集到这个部位后驻留在表皮中。在这项研究中，我们证明了长期持久的表皮T-RM优先在网站的先前感染，尽管持续迁移。长时间内皮肤内T-RM迁移的计算模拟显示，缓慢的随机迁移速率有效地将这些记忆细胞限制在它们形成的皮肤区域内。值得注意的是，T-RM的形成涉及表皮中树突状表皮γ δ T细胞数量的伴随局部减少，表明这些群体持续相互排斥，并可能竞争局部生存信号。因此，我们表明，芳烃受体（一种对皮肤中树枝状表皮γ δ T细胞维持很重要的转录因子）的表达也有助于皮肤T-RM的持续存在。总之，这些数据表明，皮肤组织驻留的记忆T细胞持续存在于严格调节的表皮T细胞龛内。
Barrier tissues such as the skin contain various populations of immune cells that contribute to protection from infections. These include recently identified tissue-resident memory T cells (T-RM). In the skin, these memory CD8(+) T cells reside in the epidermis after being recruited to this site by infection or inflammation. In this study, we demonstrate prolonged persistence of epidermal T-RM preferentially at the site of prior infection despite sustained migration. Computational simulation of T-RM migration within the skin over long periods revealed that the slow rate of random migration effectively constrains these memory cells within the region of skin in which they form. Notably, formation of T-RM involved a concomitant local reduction in dendritic epidermal gamma delta T-cell numbers in the epidermis, indicating that these populations persist in mutual exclusion and may compete for local survival signals. Accordingly, we show that expression of the aryl hydrocarbon receptor, a transcription factor important for dendritic epidermal gamma delta T-cell maintenance in skin, also contributes to the persistence of skin T-RM. Together, these data suggest that skin tissue-resident memory T cells persist within a tightly regulated epidermal T-cell niche.