Host Lipids in Positive-Strand RNA Virus Genome Replication
Host Lipids in Positive-Strand RNA Virus Genome Replication
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DOI：
10.3389/fmicb.2019.00286
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发表时间：
2019-02
影响因子：
5.2
通讯作者：
Zhenlu Zhang;Guijuan He;N. Filipowicz;G. Randall;G. Belov;B. G. Kopek;Xiaofeng Wang
中科院分区：
文献类型：
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作者：
Zhenlu Zhang;Guijuan He;N. Filipowicz;G. Randall;G. Belov;B. G. Kopek;Xiaofeng Wang
膜结合是正链RNA病毒[(+)RNA病毒]基因组复制的标志。所有研究良好的(+)RNA病毒都通过精心安排的病毒-宿主相互作用来重塑宿主膜和脂质代谢，以创造合适的微环境，以便在宿主细胞中生存和茁壮成长。最近的研究表明，宿主脂类作为细胞膜的主要成分，在多种(+)RNA病毒的复制中起着关键作用。本文综述了(+)RNA病毒如何操纵宿主的脂质合成和代谢以促进其基因组RNA的复制，以及干扰细胞脂质代谢如何影响病毒的复制。
Membrane association is a hallmark of the genome replication of positive-strand RNA viruses [(+)RNA viruses]. All well-studied (+)RNA viruses remodel host membranes and lipid metabolism through orchestrated virus-host interactions to create a suitable microenvironment to survive and thrive in host cells. Recent research has shown that host lipids, as major components of cellular membranes, play key roles in the replication of multiple (+)RNA viruses. This review focuses on how (+)RNA viruses manipulate host lipid synthesis and metabolism to facilitate their genomic RNA replication, and how interference with the cellular lipid metabolism affects viral replication.