TIGER: A software system for fine-mapping quantitative trait loci
TIGER: A software system for fine-mapping quantitative trait loci
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DOI：
10.5194/aab-51-402-2008
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发表时间：
2008-01-01
影响因子：
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通讯作者：
Reinsch, Norbert
中科院分区：
文献类型：
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作者：
Baes, Christine;Reinsch, Norbert
对家畜重要经济性状表型变异有重要影响的数量性状基因座的定位已成为动物基因组学的重要目标。几个这样的基因座已大致确定使用连锁分析，但现在的重点已经转移到精细定位和精确定位因果突变。在一个国家合作研究项目的范围内，开发了软件系统TIGER。TIGER是一个UNIX脚本，连接几个单独的Fortran程序，用于精细绘图数据的综合方差分量分析。该软件从原始基因型数据、系谱和标记图信息开始，以每个推定的数量性状位点位置的基于剩余最大似然的检验结束，为用户提供了能够进行连锁分析、连锁不平衡分析和组合连锁/连锁不平衡分析的“一体化”软件包。该软件系统已应用于4个黄牛染色体的精细作图项目。
The localisation of quantitative trait loci which contribute significantly to phenotype variation of economically important traits in domestic species has become an important goal in animal genomics. Several such loci have been roughly identified using linkage analyses; however the focus has now shifted towards fine mapping and pinpointing causal mutations. In the context of a cooperative national research project, the software system TIGER was developed. TIGER is a UNIX script linking several individual Fortran programmes and is used for comprehensive variance component analysis of fine mapping data. Starting with raw genotype data, pedigree and marker map information and ending with a residual maximum likelihood-based test for each putative quantitative trait locus position, the software provides the user with an 'all in one' package capable of linkage analysis, linkage disequilibrium analysis and combined linkage/linkage disequilibrium analysis. The software system has been employed in 4 fine mapping projects on 4 distinct cattle chromosomes.