Abnormal motor cortex organization contralateral to early upper limb amputation in humans
Abnormal motor cortex organization contralateral to early upper limb amputation in humans
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DOI：
10.1016/s0304-3940(99)00105-6
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发表时间：
1999-03-19
影响因子：
2.5
通讯作者：
Weiller, C
中科院分区：
文献类型：
--
作者：
Dettmers, C;Liepert, J;Weiller, C
我们对一位21岁的病人进行了一项功能性磁共振成像（fMRI）研究，使用单层FLASH技术，并进行了经颅磁刺激（TMS）研究。他7岁时左上肢截肢。截肢残端的前屈产生了一个不寻常的，广泛的激活对侧的运动。经颅磁刺激显示截肢残端三角肌皮质运动输出区扩大。配对磁刺激的应用表明皮质内抑制（ICI）减少。T1加权图像表明截肢对侧的中央沟缺乏特征性形状。除了以前的功能研究，这些新的结构数据表明，成熟的中央沟的发展，对侧手的日常实践，可能直到青春期。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
We performed both a functional magnetic resonance imaging (fMRI) study using single slice FLASH technique and an investigation with transcranial magnetic stimulation (TMS) in a 21-year-old patient. He had suffered a left upper extremity amputation at age 7. Anteflexion of the amputation stump produced an unusual, broad activation contralateral to the movement. TMS revealed an enlarged cortical motor output area of the deltoid muscle at the amputation stump. Application of paired magnetic stimulation demonstrated decreased intracortical inhibition (ICI). A T1-weighted image indicated a lack of the characteristic shape of the central sulcus contralateral to the amputation. In addition to previous functional studies, these new structural data suggest that maturation of the central sulcus develops in response to daily practice of the contralateral hand, possibly until adolescence. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.