Correlation between apparent diffusion coefficient of magnetic resonance imaging and tumor-infiltrating lymphocytes in breast cancer
Correlation between apparent diffusion coefficient of magnetic resonance imaging and tumor-infiltrating lymphocytes in breast cancer
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DOI：
10.1007/s11547-019-01008-w
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发表时间：
2019-07-01
影响因子：
8.9
通讯作者：
Giovagnoni, Andrea
中科院分区：
文献类型：
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作者：
Fogante, Marco;Tagliati, Corrado;Giovagnoni, Andrea
目的探讨乳腺癌表观扩散系数（ADC）值与肿瘤浸润淋巴细胞（TIL）水平的相关性。第二个目标是评估是否有其他组织病理学特征，可能会影响平均ADC value.MethodsIn这4年的回顾性研究，包括125例接受根治性或改良乳腺切除术的单灶性BC。所有受试者术前均使用相同的1.5-T机器和方案进行MRI检查，包括STIR、DWI和DCE序列。根据TIL评分，将BC分为两组：无-低TIL（10%）。使用t检验将平均ADC值与TIL组相关。结果肺癌患者中，无-低TIL者66例（52.8%），中-高TIL者59例（47.2%）;平均ADC值为1.05 ± 0.19 *10（-3）mm（2）s（-1）。无-低TIL组的平均ADC值低于中-高TIL组（0.96 +/- 0.18*10（-3）mm（2）s（-1）vs 1.14 +/- 0.16*10（-3）mm（2）s（-1）; p
PurposeTo evaluate a possible correlation between apparent diffusion coefficient (ADC) value and tumor-infiltrating lymphocytes (TILs) level in breast cancer (BC). A second objective was to assess whether there were other histopathologic features that could affect mean ADC value.MethodsIn this 4-year retrospective study were included 125 patients who underwent radical or modified mastectomy for monofocal BC. All subjects had performed preoperative MRI with the same 1.5-T machine and protocol, which consisted of STIR, DWI and DCE sequences. Based on TIL score, BCs were stratified into two groups: absent-low TIL (10%). The t test was used to correlate mean ADC value with TIL groups. Receiver operating characteristic curve and Youden index were used in order to identify ADC value threshold to distinguish the two TIL groups.ResultsBC patients with absent-low TIL level and medium-high TIL one were, respectively, 66 (52.8%) and 59 (47.2%). Mean ADC value was 1.050.19*10(-3)mm(2)s(-1). Absent-low TIL group showed a lower mean ADC value than medium-high TIL one (0.96 +/- 0.18*10(-3)mm(2)s(-1) vs 1.14 +/- 0.16*10(-3)mm(2)s(-1); p