Differential effects of intranasal oxytocin on sexual experiences and partner interactions in couples
Differential effects of intranasal oxytocin on sexual experiences and partner interactions in couples
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DOI：
10.1016/j.yhbeh.2014.01.009
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发表时间：
2014-03-01
影响因子：
3.5
通讯作者：
Kruger, Tillmann H. C.
中科院分区：
文献类型：
--
作者：
Behnia, Behnoush;Heinrichs, Markus;Kruger, Tillmann H. C.
关于神经肽催产素（OXT）对人类性行为和伴侣互动的影响的知识仍然有限。基于我们以前的研究，我们假设，OXT应该能够积极影响性功能和夫妇interactions.Employing一个自然的设置，涉及29个健康的异性恋夫妇（n = 58），我们分析了急性影响鼻内给药OXT（24 IU）的性驱动，唤醒，性高潮和顽固性方面的性行为与合作伙伴的互动。通过心理测量工具（急性性体验量表，亚利桑那州性体验量表）以及生物标志物（如皮质醇，α-淀粉酶和心率）评估数据，鼻内OXT给药并没有改变性功能的“经典”参数，如性欲，唤醒或阴茎勃起和润滑。然而，方差分析和分层线性模型（HLM）揭示了与性高潮/性高潮后间隔以及伴侣相互作用参数相关的特定效应。根据HLM分析，OXT增加了性高潮的强度，性交后的满意度和研究参与的效果。根据ANOVA分析，这些影响在男性中更为明显。此外，男性在与OXT给药性交后表现出更高水平的性饱腹感。女性感到更放松，亚组显示出更好的分享性欲或同情伴侣的能力。效应量为小到中等。生物标志物表明中度的心理生理激活，但不受OXT，性别或避孕方法。使用自然的设置，夫妇鼻内OXT管理产生差异性的影响参数的性功能和合作伙伴的相互作用。这些结果值得进一步调查，包括性和关系问题的主题。(C)2014爱思唯尔公司All rights reserved.
Knowledge about the effects of the neuropeptide oxytocin (OXT) on human sexual behaviors and partner interactions remains limited. Based on our previous studies, we hypothesize that OXT should be able to positively influence parameters of sexual function and couple interactions.Employing a naturalistic setting involving 29 healthy heterosexual couples (n = 58 participants), we analyzed the acute effects of intranasally administered OXT (24 IU) on sexual drive, arousal, orgasm and refractory aspects of sexual behavior together with partner interactions. Data were assessed by psychometric instruments (Acute Sexual Experiences Scale, Arizona Sexual Experience Scale) as well as biomarkers, such as cortisol, alpha-amylase and heart rate.Intranasal OXT administration did not alter "classical" parameters of sexual function, such as sexual drive, arousal or penile erection and lubrication. However, analysis of variance and a hierarchical linear model (HLM) revealed specific effects related to the orgasmic/post-orgasmic interval as well as parameters of partner interactions. According to HLM analysis, OXT increased the intensity of orgasm, contentment after sexual intercourse and the effect of study participation. According to ANOVA analysis, these effects were more pronounced in men. Men additionally indicated higher levels of sexual satiety after sexual intercourse with OXT administration. Women felt more relaxed and subgroups indicated better abilities to share sexual desires or to empathize with their partners. The effect sizes were small to moderate. Biomarkers indicated moderate psychophysiological activation but were not affected by OXT, gender or method of contraception.Using a naturalistic setting, intranasal OXT administration in couples exerted differential effects on parameters of sexual function and partner interactions. These results warrant further investigations, including subjects with sexual and relationship problems. (C) 2014 Elsevier Inc. All rights reserved.