Cerebral amyloid angiopathy-related leukoencephalopathy: Successful steroid therapy treatment for neurological deficits and subcortical white matter lesions partly involving the cortical gray matter.
Cerebral amyloid angiopathy-related leukoencephalopathy: Successful steroid therapy treatment for neurological deficits and subcortical white matter lesions partly involving the cortical gray matter.
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脑淀粉样血管病相关的白质脑病：成功的类固醇疗法治疗神经功能缺陷和部分涉及皮质灰质的皮质下白质病变。
DOI：
10.1111/ncn3.101
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发表时间：
2014
影响因子：
0.4
通讯作者：
et al.
中科院分区：
文献类型：
--
作者：
Takenobu Murakami;Julia Morimoto;Akihiko Hoshi;et al.
1例76岁女性患者发生亚急性认知功能下降、意识障碍和右侧轻偏瘫。磁共振成像显示不对称的白色物质或皮质灰质病变，以及多发性脑微出血。活检脑标本的病理学研究显示血管壁中存在淀粉样β蛋白沉积。重复类固醇脉冲治疗改善了临床症状，并解决了皮质-皮质下病变。淀粉样β蛋白沉积的脑淀粉样血管病相关白质脑病患者应考虑类固醇治疗。
A 76‐year‐old woman developed subacute cognitive decline, consciousness impairment and right hemiparesis. Magnetic resonance imaging showed asymmetric white matter or cortical gray matter lesions, and multiple cerebral microbleeds. Pathological studies of biopsied brain specimen disclosed amyloid β‐protein deposits in the vessel walls. Repeated steroid‐pulse therapy improved clinical symptoms and resolved the cortico‐subcortical lesions. Steroid therapy should be considered for patients with amyloid β‐protein deposition in cerebral amyloid angiopathy‐related leukoencephalopathy.