Molecular mechanisms of normal iron homeostasis.
Molecular mechanisms of normal iron homeostasis.
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DOI：
10.1182/asheducation-2009.1.207
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发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Enns, Caroline A
中科院分区：
文献类型：
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作者：
Zhang, An-Sheng;Enns, Caroline A
人类拥有优雅的控制机制，通过协调调节铁的吸收、铁的循环和储存铁的动员来维持铁的动态平衡。饮食中铁的吸收受低氧诱导因子(HIF)信号和肠道细胞中铁调节蛋白(IRPS)的局部调节，并受中枢铁调节激素肝脏海普西丁的系统调节。海普西丁不仅控制铁吸收的速度，而且还通过负向调节铁转运蛋白的功能来决定铁从储存中的动员，铁转运蛋白是迄今为止唯一已发现的细胞铁输出蛋白。肝脏海普西丁的调节是通过不同的信号通路，通过多种蛋白质的协同活动来完成的。最近的研究极大地扩展了对海普西丁表达和骨形态发生蛋白(BMP)信号、红系因子和炎症调节的了解。在这篇综述中，我们主要关注最近发现的蛋白质在铁稳态调节中的作用。
Humans possess elegant control mechanisms to maintain iron homeostasis by coordinately regulating iron absorption, iron recycling, and mobilization of stored iron. Dietary iron absorption is regulated locally by hypoxia inducible factor (HIF) signaling and iron-regulatory proteins (IRPs) in enterocytes and systematically by hepatic hepcidin, the central iron regulatory hormone. Hepcidin not only controls the rate of iron absorption but also determines iron mobilization from stores through negatively modulating the function of ferroportin, the only identified cellular iron exporter to date. The regulation of hepatic hepcidin is accomplished by the coordinated activity of multiple proteins through different signaling pathways. Recent studies have greatly expanded the knowledge in the understanding of hepcidin expression and regulation by the bone morphogenetic protein (BMP) signaling, the erythroid factors, and inflammation. In this review, we mainly focus on the roles of recently identified proteins in the regulation of iron homeostasis.