Postnatal Feeding With a Fat Rich Diet Induces Precocious Puberty Independent of Body Weight, Body Fat, and Leptin Levels in Female Mice
Postnatal Feeding With a Fat Rich Diet Induces Precocious Puberty Independent of Body Weight, Body Fat, and Leptin Levels in Female Mice
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产后喂养富含脂肪的饮食可导致雌性小鼠性早熟，与体重、体脂和瘦素水平无关
DOI：
10.3389/fendo.2019.00758
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发表时间：
2019-11-08
影响因子：
5.2
通讯作者：
Fu, Junfen
中科院分区：
文献类型：
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作者：
Ullah, Rahim;Raza, Ali;Fu, Junfen
青春期通常发生在一个人储存了足够的能量时。以往的报道表明，在孕期和哺乳期，由小胎次或母体高脂饮食(HFD)喂养引起的出生后过度喂养会增加体重、体脂和血浆瘦素水平，并诱导性早熟。体重、体脂和瘦素在出生后HFD诱导性早熟中的作用还知之甚少。在这项研究中，我们调查了出生后喂养HFD是否诱导性早熟与体重、体脂和瘦素水平无关。选用不同胎次、不同暴露时间的HFD仔猪，生产不同体重、不同体脂的HFD仔猪。在不同时间点检测体重、体脂和血浆激素水平，以确定它们与HFD诱导的性早熟的关系。我们的结果表明，出生后饲喂高脂饲料增加了体重、体脂和脂肪细胞的大小，并诱导性早熟。HFD诱导性早熟与体重、体脂和血浆瘦素水平无关。大多数组的血浆促性腺激素、雌二醇、睾酮和胰岛素水平相似。我们的结果共同表明，出生后喂养HFD诱导性早熟不依赖于体重、体脂和血浆瘦素水平。我们的结果还表明，喂养HFD是青春期开始的刺激因素，但需要进一步研究才能了解它是如何诱导性早熟的。
Puberty generally occurs when an individual has stored a sufficient amount of energy. Previous reports have shown that postnatal overfeeding, induced by a small litter size or maternal high fat diet (HFD) feeding during gestation and lactation increases body weight (BW), body fat, plasma leptin levels, and induces precocious puberty. The role of BW, body fat, and leptin in postnatal HFD-induced precocious puberty is poorly understood. In this study, we investigated if postnatal HFD feeding induces precocious puberty independent of BW, body fat, and leptin levels. Different litter sizes and different exposure time to HFD were used to produce HFD feeding pups with different BW and body fat. BW, body fat, and plasma hormones levels were checked at different time points to test their relation with HFD-induced precocious puberty. Our results showed that postnatal HFD feeding increases BW, body fat, adipocyte size, and induces precocious puberty. HFD-induced precocious puberty was independent of BW, body fat, and plasma leptin levels. Plasma gonadotrophin, estradiol, testosterone and insulin levels were comparable in most of the groups. Our results collectively suggest that postnatal HFD feeding induces precocious puberty independent of BW, body fat and plasma leptin levels. Our results also suggest that HFD feeding acts as a stimulator for puberty onset but further studies are needed to understand how it induces precocious puberty.