Adherence to Inhaled Therapy in Patients with COPD Associated to Pneumoconiosis.
Adherence to Inhaled Therapy in Patients with COPD Associated to Pneumoconiosis.
复制标题
尘肺相关慢性阻塞性肺病患者坚持吸入治疗。
DOI：
10.2147/copd.s327686
复制
发表时间：
2021
影响因子：
2.8
通讯作者：
Chen P
中科院分区：
文献类型：
--
作者：
Peng Y;Duan J;Li X;Zeng Y;Zhou Z;Deng M;Ouyang R;Chen Y;Cai S;Chen P
尘肺病具有高患病率的慢性阻塞性肺疾病（COPD），呼吸系统发病率和死亡率。本研究的目的是在现实世界的临床环境中检查尘肺合并COPD患者的特征和对吸入治疗的依从性。对一组肺尘肺合并慢性阻塞性肺病患者进行随访，随访时间为2年，患者处方中至少有一种长效吸入药物。基线收集人口统计学和copd相关特征。基线上，经年龄调整后，粉尘暴露时间与最近一年急性发作次数呈正相关。COPD评估工具（CAT）评分、改良的医学研究委员会呼吸困难量表（mMRC）分级、AE次数与fev1前值密切相关。在最初招募的296名参与者中，213名参与者完成了为期2年的随访。122例（57.28%）吸入治疗不依从。不遵医术最常见的原因是“短期使用控制性药物后症状缓解”（53.28%）。非依从性患者报告的体重指数（BMI）较高，去年AE事件较少，fev1前值较高，fev1后值较高，CAT， mMRC评分较低。高fev1前值（OR = 1.04, CI = 1.018-1.064）和低mMRC评分（OR = 0.406, CI = 0.214-0.771）是发现与不依从相关的危险因素。大多数合并COPD的尘肺患者吸入治疗依从性不理想。以证据为基础、增强依从性的干预措施应针对不那么严重的主题。
Pneumoconiosis has high prevalence of chronic obstructive pulmonary disease (COPD), respiratory morbidity, and mortality. The aim of the present study was to examine patient characteristics and adherence to inhaled therapy among pneumoconiosis with COPD in a real-world clinical setting. A cohort of pneumoconiosis patients with COPD prescript with at least one type of long-acting inhaled drug was followed for adherence for 2 years. Demographic and COPD-related characteristics were collected in baseline. In baseline, after adjusting for age, dust exposure duration positively correlated with number of acute exacerbation (AE) frequency in the last year. There were close associations among COPD Assessment Tool (CAT) score, modified Medical Research Council Dyspnea Scale (mMRC) grade, number of AE, and pre-FEV1 value. Of 296 participants originally recruited, 213 participants finished the 2-year follow-up for adherence. 122 (57.28%) were non-adherent to inhaled therapy. The most common reason for non-adherence was “relief of symptoms after short-term controller medication use” (53.28%). Patients who were non-adherent reported higher body mass index (BMI), less AE events in the last year, higher pre-FEV1 value, higher post-FEV1 value and low CAT, mMRC scores compared to adherent in baseline. High pre-FEV1 value (OR = 1.04, CI = 1.018–1.064) and low mMRC scores (OR = 0.406, CI = 0.214–0.771) were risk factors found associated with non-adherence. A majority of pneumoconiosis patients complicated with COPD have suboptimal inhaled therapy adherence. Evidence-based, adherence-enhancing interventions should be targeted on less severe subjects.
影响因子：
2.3
作者：
Incorvaia C;Riario-Sforza GG
通讯作者：
Riario-Sforza GG