Charting shared developmental trajectories of cortical thickness and structural connectivity in childhood and adolescence
Charting shared developmental trajectories of cortical thickness and structural connectivity in childhood and adolescence
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DOI：
10.1002/hbm.24726
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发表时间：
2019-07-16
影响因子：
4.8
通讯作者：
Seal, Marc L.
中科院分区：
文献类型：
--
作者：
Ball, Gareth;Beare, Richard;Seal, Marc L.
大脑皮层被组织成广泛的层级功能系统，具有由皮层形态的宏观测量所反映的独特神经解剖学特征。弥散加权磁共振成像能够描绘区域连接性，其变化反映了白质束的持续成熟。这些发育过程与认知功能发展的时间在本质上是相关联的。在这项研究中，我们使用一种数据驱动的多元方法——非负矩阵分解，在一个大型儿童队列（n = 456）中定义共同变化且与皮层连接的特定子网络相关的皮层区域。我们发现，3到21岁之间的年龄与额顶叶区域的皮层加速变薄有关，而初级运动和感觉区域的相对变薄则较慢。总之，所导出的一组皮层成分的个体特异性权重可以组合起来预测实际年龄。结构连接网络显示，半球内连接强度相对增加，而半球间连接强度则与皮层变化一致地发生变化。我们在一个独立样本中证实了我们的发现。
The cortex is organised into broadly hierarchical functional systems with distinct neuroanatomical characteristics reflected by macroscopic measures of cortical morphology. Diffusion-weighted magnetic resonance imaging allows the delineation of areal connectivity, changes to which reflect the ongoing maturation of white matter tracts. These developmental processes are intrinsically linked with timing coincident with the development of cognitive function. In this study, we use a data-driven multivariate approach, nonnegative matrix factorisation, to define cortical regions that co-vary together across a large paediatric cohort (n = 456) and are associated with specific subnetworks of cortical connectivity. We find that age between 3 and 21 years is associated with accelerated cortical thinning in frontoparietal regions, whereas relative thinning of primary motor and sensory regions is slower. Together, the subject-specific weights of the derived set of cortical components can be combined to predict chronological age. Structural connectivity networks reveal a relative increase in strength in connection within, as opposed to between hemispheres that vary in line with cortical changes. We confirm our findings in an independent sample.