Decreased segregation of brain systems across the healthy adult lifespan
Decreased segregation of brain systems across the healthy adult lifespan
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DOI：
10.1073/pnas.1415122111
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发表时间：
2014-11-18
影响因子：
11.1
通讯作者：
Wig, Gagan S.
中科院分区：
文献类型：
--
作者：
Chan, Micaela Y.;Park, Denise C.;Wig, Gagan S.
健康老龄化与大脑功能的特化程度降低有关。这种特征主要集中在描述神经元和大脑区域层面上伴随年龄增长而出现的特化差异。我们扩展了这项工作，以描述一个健康成年寿命样本（n = 210；20 - 89岁）中系统层面的特化差异。一个图论框架被用于指导对功能性磁共振成像静息态数据的分析，并描述单个大脑网络连接性的系统层面差异。年轻人的大脑系统在系统内和系统间相关性上呈现出一种平衡，这是分离和特化组织的特征。年龄增长伴随着大脑系统分离程度的降低。与参与感觉输入和运动输出处理的系统相比，介导“联想”操作的系统在整个成年寿命中呈现出一种独特的分离降低模式。尤为重要的是，联想系统分离的程度可预测长期记忆功能，且与个体年龄无关。
Healthy aging has been associated with decreased specialization in brain function. This characterization has focused largely on describing age-accompanied differences in specialization at the level of neurons and brain areas. We expand this work to describe systems-level differences in specialization in a healthy adult lifespan sample (n = 210; 20-89 y). A graph-theoretic framework is used to guide analysis of functional MRI resting-state data and describe systems-level differences in connectivity of individual brain networks. Young adults' brain systems exhibit a balance of within-and between-system correlations that is characteristic of segregated and specialized organization. Increasing age is accompanied by decreasing segregation of brain systems. Compared with systems involved in the processing of sensory input and motor output, systems mediating "associative" operations exhibit a distinct pattern of reductions in segregation across the adult lifespan. Of particular importance, the magnitude of association system segregation is predictive of long-term memory function, independent of an individual's age.