Familial risks of squamous cell carcinoma of the head and neck: Retrospective case-control study
Familial risks of squamous cell carcinoma of the head and neck: Retrospective case-control study
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DOI：
10.1136/bmj.313.7059.716
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发表时间：
1996-09-21
影响因子：
105.7
通讯作者：
Narod, SA
中科院分区：
文献类型：
--
作者：
Foulkes, WD;Brunet, JS;Narod, SA
确定遗传因素对头颈部鳞状细胞癌发病率的影响。设计-历史队列研究。头颈部鳞状细胞癌病例的一级亲属组成暴露队列，病例配偶的一级亲属组成对照非暴露队列。作为对照，156例索引病例的配偶的934名一级亲属。主要结局指标-病例一级亲属发生鳞状细胞癌的相对风险与配偶一级亲属发生鳞状细胞癌的风险相比。结果-如果索引病例患有头颈部鳞状细胞癌，则发生头颈部癌的校正相对风险为3.79（95%置信区间1.11至13.0）。在其他部位，与癌症家族史相关的风险没有显著增加。头部和颈部鳞状细胞癌的调整后的相对危险度为7.89（1.50至41.6），在一级亲属的多原发性头颈部tumors. Conclusions，这些数据表明，遗传因素是重要的头颈部癌的病因，特别是多原发性癌症的患者。鉴于这些受试者长期暴露于致癌物，这些遗传因素可能在改变致癌物活性或宿主对致癌物的抵抗力方面发挥作用。遗传因素可能是重要的人与环境诱发的癌症。
Objective-To determine the contribution of inheritance to the incidence of squamous cell carcinoma of the head and neck.Design-Historical cohort study. First degree relatives of cases with squamous cell carcinoma of the head and neck made up the exposed cohort and first degree relatives of spouses of cases made up the comparison unexposed cohort.Setting-Ear, nose, and throat clinic in a large metropolitan teaching hospital.Subjects-1429 first degree relatives of 242 index cases of squamous cell carcinoma of the head and neck; as controls, 934 first degree relatives of the spouses of 156 index cases.Main outcome measures-Relative risk of developing squamous cell carcinoma in first degree relatives of cases compared with risk in first degree relatives of spouses.Results-The adjusted relative risk for developing head and neck cancer if the index case had squamous cell carcinoma of the head and neck was 3.79 (95% confidence interval 1.11 to 13.0). There were no significantly increased risks associated with a family history of cancer at other sites. The adjusted relative risk for squamous cell carcinoma of the head and neck was 7.89 (1.50 to 41.6) in first degree relatives of patients with multiple primary head and neck tumours.Conclusions-These data suggest that genetic factors are important in the aetiology of head and neck cancer, in particular for patients with multiple primary cancers. Given the prolonged exposure of these subjects to carcinogens, these genetic factors may have a role in modifying carcinogen activity or in host resistance to carcinogens. Inherited factors may be important in persons with environmentally induced cancers.