Elastocapillary Instability in Mitochondrial Fission
Elastocapillary Instability in Mitochondrial Fission
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DOI：
10.1103/physrevlett.115.088102
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发表时间：
2015-08-20
影响因子：
8.6
通讯作者：
Husson, Julien
中科院分区：
文献类型：
--
作者：
Gonzalez-Rodriguez, David;Sart, Sebastien;Husson, Julien
线粒体是不断发生裂变和融合事件的动态细胞器。这些动态过程严格调节线粒体形态，对细胞生理至关重要。在这里，我们提出弹性毛细管机械不稳定性作为线粒体裂变的机制。我们在实验中通过破坏细胞质膜来诱导线粒体裂变。我们提出了一个稳定性分析，成功地解释了观察到的裂变波长和线粒体形态在裂变事件发生中的作用。我们的结果表明，流体力学定律可以描述线粒体的形态和动力学。
Mitochondria are dynamic cell organelles that constantly undergo fission and fusion events. These dynamical processes, which tightly regulate mitochondrial morphology, are essential for cell physiology. Here we propose an elastocapillary mechanical instability as a mechanism for mitochondrial fission. We experimentally induce mitochondrial fission by rupturing the cell's plasma membrane. We present a stability analysis that successfully explains the observed fission wavelength and the role of mitochondrial morphology in the occurrence of fission events. Our results show that the laws of fluid mechanics can describe mitochondrial morphology and dynamics.