Retinol binding protein 4 is associated with adiposity-related co-morbidity risk factors in children.
Retinol binding protein 4 is associated with adiposity-related co-morbidity risk factors in children.
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DOI：
10.1515/jpem.2011.297
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Rosenbaum M
中科院分区：
文献类型：
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作者：
Conroy R;Espinal Y;Fennoy I;Accacha S;Boucher-Berry C;Carey DE;Close S;DeSantis D;Gupta R;Hassoun AA;Iazzetti L;Jacques FJ;Jean AM;Michel L;Pavlovich K;Rapaports R;Rosenfeld W;Shamoon E;Shelov S;Speiser PW;Ten S;Rosenbaum M
在成人中，视黄醇结合蛋白4（RBP 4）水平升高与肥胖相关共病的生化标志物相关，包括胰岛素抵抗、血脂异常、高血压和腹部肥胖。本研究探讨了纽约市公立学校系统中不同种族儿童青春期早期至中期人群中RBP 4与肥胖共病危险因素之间的关系。我们分析了人体测量（体重指数、体脂百分比、腰围）、代谢（脂质、葡萄糖）和炎症106名学龄儿童中与肥胖相关的合并症和血清丙氨酸氨基转移酶（ALT）的（TNF-α、白细胞介素-6、C-反应蛋白、脂联素）标志物（65名男性，41名女性）11-15岁（平均值± SD = 13.0 ± 0.1岁），参加了减少肥胖和糖尿病（ROAD）项目。采用定量胰岛素敏感性检查指数评价胰岛素敏感性。胰岛素分泌能力以急性胰岛素反应和葡萄糖处置指数来衡量。血清RBP 4与ALT、甘油三酯和甘油三酯z评分显著正相关，与脂联素呈负相关。校正体脂百分比、年龄和性别后，ALT和脂联素的相关性仍然显著。RBP 4与ALT、葡萄糖代谢指数和脂联素的关系存在种族差异。在青少年早期至中期，RBP 4的循环浓度与肥胖相关共病的多种风险因素相关。当校正%体脂时，许多相关性仍然存在，这表明RBP 4可以被视为儿童肥胖相关共病风险的独立标志物。
In adults, elevated levels of retinol binding protein 4 (RBP4) have been associated with biochemical markers of adiposity-related co-morbidities including insulin resistance, dyslipidemia, hypertension, and abdominal obesity. This study examined the relationship between RBP4 and risk factors for co-morbidities of adiposity in a population of ethnically diverse children in early- to mid-adolescence in the public school system of New York City. We analyzed anthropometric (body mass index, % body fat, waist circumference), metabolic (lipids, glucose), and inflammatory (TNF-α, interleukin-6, C-reactive protein, adiponectin) markers for adiposity-related co-morbidities and serum alanine aminotransferase (ALT) in 106 school children (65 males, 41 females) 11–15 years of age (mean ± SD = 13.0 ± 0.1 years) who were enrolled in the Reduce Obesity and Diabetes (ROAD) project. Insulin sensitivity was assessed by quantitative insulin sensitivity check index. Insulin secretory capacity was measured as acute insulin response and glucose disposal index. Serum RBP4 was significantly correlated directly with ALT, triglycerides, and triglyceride z-score, and inversely correlated with adiponectin. Correlations with ALT and adiponectin remained significant when corrected for % body fat, age, and gender. There were significant ethnic differences in the relationship of RBP4 to ALT, glucose disposal index and adiponectin. In early- to mid-adolescents, circulating concentrations of RBP4 are correlated with multiple risk factors for adiposity-related co-morbidities. The observation that many associations persisted when corrected for % body fat, suggests that RBP4 can be viewed as an independent marker of adiposity-related co-morbidity risk in children.