Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2
Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2
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DOI：
10.1016/0304-3940(90)90025-5
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发表时间：
1990-12
影响因子：
2.5
通讯作者：
Vijendra K. Singh;S. C. Leu
中科院分区：
文献类型：
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作者：
Vijendra K. Singh;S. C. Leu
基于低分子神经激素促肾上腺皮质激素释放因子(CRF)的免疫调节作用，我们观察了CRF对正常人外周血单个核细胞产生IL-1和IL-2活性的影响。IL-1和IL-2的产生被纳摩尔浓度的CRF本身所刺激。此外，CRF还能增加脂多糖诱导的IL-1的产生和植物血凝素诱导的IL-2的产生。这些结果表明，CRF可能通过作为神经内分泌-免疫通路的血液媒介来调节免疫系统细胞的功能。
Based upon an immunomodulatory role for Corticotropin-Releasing Factor (CRF), a low molecular weight neurohormone, we investigated the effect of CRF on the production of interleukin-1 (IL-1) and interleukin-2 (IL-2) activities of mononuclear cells isolated from the peripheral blood of healthy subjects. The production of both IL-1 and IL-2 was stimulated by a nanomolar concentration of CRF by itself. In addition, CRF augmented the production of IL-1 as induced by lipopolysaccharide and the production of IL-2 as induced by phytohemagglutinin. These results suggest that CRF modulates the function of the cells of the immune system presumably by acting as a blood-borne mediator of the neuroendocrine-immune pathways.