Defective expression of high affinity IL-2 receptors on activated T cells from aged humans.
Defective expression of high affinity IL-2 receptors on activated T cells from aged humans.
复制标题
老年人激活的 T 细胞上高亲和力 IL-2 受体的表达有缺陷。
DOI：
10.1093/intimm/2.3.239
复制
发表时间：
1990
影响因子：
4.4
通讯作者：
Weksler,ME
中科院分区：
文献类型：
--
作者：
Schwab,R;Pfeffer,LM;Szabo,P;Gamble,D;Schnurr,CM;Weksler,ME
The proliferative response of T cells from aged humans to a number of mitogens is significantly reduced. We report here that there is a decrease in high affinity IL-2 receptor (IL-2R) expression on activated T cells from aged humans. Scatchard analysis of the binding of [125l]IL-2 demonstrates fewer high affinity IL-2 binding sites. Autoradiographic techniques demonstrate that this results from there being fewer activated T cells from old as compared to young donors that express high affinity IL-2R. However, T cells from old donors that do not express high affinity IL-2 binding sites express both the IL-2 binding 55 and 75 kd chains. Thus, although the two IL-2 binding peptldes are expressed on activated T cells from old donors, expression of the high affinity IL-2R Is reduced. This may explain the decreased ability of T cells from old donors to respond to IL-2. The impaired ability of activated T cells from old donors to express high affinity IL-2R while expressing the 55 and 75 kd chains may provide insights Into the mechanisms of IL-2 Interactions with its receptor.
