Dietary calcium supplementation suppresses bone formation in magnesium-deficient rats
Dietary calcium supplementation suppresses bone formation in magnesium-deficient rats
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DOI：
10.1024/0300-9831.76.3.111
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发表时间：
2006-05-01
影响因子：
2.3
通讯作者：
Miwa, Misao
中科院分区：
文献类型：
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作者：
Matsuzaki, Hiroshi;Miwa, Misao
本研究旨在阐明膳食钙（Ca）补充对缺镁大鼠骨代谢的影响。将雄性Wistar大鼠按体重随机分为3组，分别饲喂对照饲粮（对照组）、缺镁饲粮（Mg-组）和钙浓度为对照两倍的缺镁饲粮（Mg(-)2Ca组）14 d。Mg-和Mg(-)2Ca组骨小梁体积显著低于对照组。Mg-组和Mg(-)2Ca组的小梁数也明显低于对照组。Mg-组和Mg(-)2Ca组骨表面矿化率、矿物附着率（MAR）和表面参考骨形成率（BFR/BS）显著低于对照组。此外，Mg(-)2Ca组MAR和BFR/BS显著低于Mg-组。这些结果表明，膳食钙补充可抑制缺镁大鼠的骨形成。
The purpose of this study was to clarify the effects of dietary calcium (Ca) supplementation on bone metabolism of magnesium (Mg-)-deficient rats. Male Wistar rats were randomized by weight into three groups, and fed a control diet (control group), a Mg-deficient diet (Mg- group) or a Mg-deficient diet having twice the control Ca concentrations (Mg(-)2Ca group) for 14 days. Trabecular bone volume was significantly lower in the Mg- and Mg(-)2Ca groups than in the control group. Trabecular number was also significantly lower in the Mg- and Mg(-)2Ca groups than in the control group. Mineralizing bone surface, mineral apposition rate (MAR), and surface referent bone formation rate (BFR/BS) were significantly lower in the Mg- and Mg(-)2Ca groups than in the the control group. Furthermore, MAR and BFR/BS were significantly lower in the Mg(-)2Ca group than in the Mg- group. These results suggest that dietary Ca supplementation supplementation suppresses bone formation in Mg-deficient rats.