Excited-State Dynamics of a Two-Photon-Activatable Ruthenium Prodrug.
Excited-State Dynamics of a Two-Photon-Activatable Ruthenium Prodrug.
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DOI：
10.1002/cphc.201501075
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发表时间：
2016-01-18
期刊：
影响因子：
--
通讯作者：
Stavros VG
中科院分区：
文献类型：
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作者：
Greenough SE;Horbury MD;Smith NA;Sadler PJ;Paterson MJ;Stavros VG
我们提出了一种新的方法来研究通过双光子吸收（TPA）激活的八面体钌（II）络合物的光动力学与通过单光子吸收（OPA）激活的等效络合物的不同。我们光活化钌II多吡啶配合物含有生物活性的单齿配体在光动力学治疗窗口（620-1000 nm），通过使用TPA和使用瞬态UV/维斯吸收光谱来阐明其反应途径。 密度泛函计算使我们能够确定的初始填充状态和动力学分析恢复的光活化寿命约为100 ps的性质。 在TPA或OPA之后显示的动力学是相同的，表明TPA前药设计可以使用从更多且容易进行的OPA研究中收集的知识。
We present a new approach to investigate how the photodynamics of an octahedral ruthenium(II) complex activated through two‐photon absorption (TPA) differ from the equivalent complex activated through one‐photon absorption (OPA). We photoactivated a RuII polypyridyl complex containing bioactive monodentate ligands in the photodynamic therapy window (620–1000 nm) by using TPA and used transient UV/Vis absorption spectroscopy to elucidate its reaction pathways. Density functional calculations allowed us to identify the nature of the initially populated states and kinetic analysis recovers a photoactivation lifetime of approximately 100 ps. The dynamics displayed following TPA or OPA are identical, showing that TPA prodrug design may use knowledge gathered from the more numerous and easily conducted OPA studies.