Perinatal exposure to low doses of dioxin can permanently impair human semen quality.
Perinatal exposure to low doses of dioxin can permanently impair human semen quality.
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DOI：
10.1289/ehp.1002134
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发表时间：
2011-05
影响因子：
10.4
通讯作者：
Brambilla P
中科院分区：
文献类型：
--
作者：
Mocarelli P;Gerthoux PM;Needham LL;Patterson DG Jr;Limonta G;Falbo R;Signorini S;Bertona M;Crespi C;Sarto C;Scott PK;Turner WE;Brambilla P
据报道，近几十年来，一些工业化地区的年轻男性精液质量有所下降。我们研究了围产期接触二恶英对精子质量和生殖激素的影响。我们调查了意大利塞维索(1976)事故后接触二恶英的母亲在1977至1984年间出生的39个儿子(平均年龄22.5岁)的精子质量和激素浓度，以及只接触背景二恶英的母亲所生的58个对照(平均年龄24.6岁)。母亲怀孕时的二恶英水平是从1976年测量的血清样本浓度推断出来的。与36个母乳喂养的对照组相比，母亲怀孕时血清二恶英浓度中值低至19ppt的21个母乳喂养的儿子的精子密度(3630万比8630万/毫升；p=0.002)、精子总数(35.8vs.231.1；p=0.02)、前进活动率(35.8vs.44.2%；p=0.03)和总活动量(3870万比9800万；p=0.002)更低。接触配方奶的18人、配方奶喂养的22人和母乳喂养的36人(受孕时母亲的二恶英本底为10ppt)没有与精子相关的差异。母乳喂养暴露组的卵泡刺激素水平高于母乳喂养对照组(4.1IU/L比2.63IU/L；p=0.03)或配方奶喂养暴露组(4.1IU/L比2.6IU/L；p=0.04)，抑制素B低于母乳喂养暴露组(70.2；母乳喂养对照组，101.8 pg/mL，p=0.01；配方奶喂养暴露组，99.9pg/mL，p=0.02)。在子宫和哺乳期，儿童暴露在相对较低剂量的二恶英中会永久性地降低精子质量。
In recent decades, young men in some industrialized areas have reportedly experienced a decrease in semen quality. We examined effects of perinatal dioxin exposure on sperm quality and reproductive hormones. We investigated sperm quality and hormone concentrations in 39 sons (mean age, 22.5 years) born between 1977 and 1984 to mothers exposed to dioxin after the accident in Seveso, Italy (1976), and 58 comparisons (mean age, 24.6 years) born to mothers exposed only to background dioxin. Maternal dioxin levels at conception were extrapolated from the concentrations measured in 1976 serum samples. The 21 breast-fed sons whose exposed mothers had a median serum dioxin concentration as low as 19 ppt at conception had lower sperm concentration (36.3 vs. 86.3 million/mL; p = 0.002), total count (116.9 vs. 231.1; p = 0.02), progressive motility (35.8 vs. 44.2%; p = 0.03), and total motile count (38.7 vs. 98 million; p = 0.01) than did the 36 breast-fed comparisons. The 18 formula-fed exposed and the 22 formula-fed and 36 breast-fed comparisons (maternal dioxin background 10 ppt at conception) had no sperm-related differences. Follicle-stimulating hormone was higher in the breast-fed exposed group than in the breast-fed comparisons (4.1 vs. 2.63 IU/L; p = 0.03) or the formula-fed exposed (4.1 vs. 2.6 IU/L; p = 0.04), and inhibin B was lower (breast-fed exposed group, 70.2; breast-fed comparisons, 101.8 pg/mL, p = 0.01; formula-fed exposed, 99.9 pg/mL, p = 0.02). In utero and lactational exposure of children to relatively low dioxin doses can permanently reduce sperm quality.