Sacral chordomas: Impact of high-dose proton/photon-beam radiation therapy combined with or without surgery for primary versus recurrent tumor
Sacral chordomas: Impact of high-dose proton/photon-beam radiation therapy combined with or without surgery for primary versus recurrent tumor
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DOI：
10.1016/j.ijrobp.2006.02.059
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发表时间：
2006-08-01
影响因子：
7
通讯作者：
Suit, Herman D.
中科院分区：
文献类型：
--
作者：
Park, Lily;DeLaney, Thomas F.;Suit, Herman D.
目的：评估高剂量质子/光子束放射治疗单独或联合手术治疗骶骨脉络膜炎的疗效。方法和材料：1982年11月~ 2002年11月单纯质子/光子放射治疗原发性和复发性骶椎脉络膜炎16例分析了局部控制、生存率和治疗相关发病率。结果：随访结果显示原发性和复发性脊索瘤患者的局部失败率有很大差异。手术和放疗的局部控制结果分别为12/14 vs. 1/7原发性和复发性病变。对于边缘阳性患者，原发组和复发组的局部对照结果分别为11例中的10例和5例中的0例;这些局部对照患者的平均随访时间为8.8年（10.3年、12.8年、17年和21年时各4例）。6例患者单独使用放射治疗，其中4例接受了>= 73.0戈伊（E）;在这4例患者中的3例中观察到2.9、4.9和7.6年的局部控制。结论：这些数据表明，原发性骶骨脊索瘤的手术和放射治疗（14例中的12例）与复发性骶骨脊索瘤（7例中的1例）不同，具有较高的局部控制率。仅接受>= 73.0戈伊（E）放射治疗的4例脊索瘤中有3例局部控制; 1例在91个月时。这表明高剂量质子/光子治疗提供了一种有效的治疗选择。(c)2006年爱思唯尔公司
Purpose: To assess the efficacy of definitive treatment of sacral chordoma by high-dose proton/photon-beam radiation therapy alone or combined with surgery.Methods and Materials: The records of 16 primary and 11 recurrent sacral chordoma patients treated from November 1982 to November 2002 by proton/photon radiation therapy alone (6 patients) or combined with surgery (21 patients) have been analyzed for local control, survival, and treatment-related morbidity. The outcome analysis is based on follow-up information as of 2005.Results: Outcome results show a large difference in local failure rate between patients treated for primary and recurrent chordomas. Local control results by surgery and radiation were 12/14 vs. 1/7 for primary and recurrent lesions. For margin-positive patients, local control results were 10 of 11 and 0 of 5 in the primary and recurrent groups, respectively; the mean follow-up on these locally controlled patients was 8.8 years (4 at 10.3, 12.8, 17, and 21 years). Radiation alone was used in 6 patients, 4 of whom received >= 73.0 Gy (E); local control was observed in 3 of these 4 patients for 2.9, 4.9, and 7.6 years.Conclusion: These data indicate a high local control rate for surgical and radiation treatment of primary (12 of 14) as distinct from recurrent (1 of 7) sacral chordomas. Three of 4 chordomas treated by >= 73.0 Gy (E) of radiation alone had local control; 1 is at 91 months. This indicates that high-dose proton/photon therapy offers an effective treatment option. (c) 2006 Elsevier Inc.