BMP signaling in development and diseases: A pharmacological perspective
BMP signaling in development and diseases: A pharmacological perspective
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DOI：
10.1016/j.bcp.2013.01.004
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发表时间：
2013-04-01
影响因子：
5.8
通讯作者：
Prashar, Paritosh
中科院分区：
文献类型：
--
作者：
Bandyopadhyay, Amitabha;Yadav, Prem Swaroop;Prashar, Paritosh
骨形态发生蛋白（BMP）信号转导在胚胎发育过程中的几个过程中，并在成人组织的稳态。许多器官如皮肤、肠绒毛、骨骼和骨髓的维持需要干细胞的持续再生和随后的分化，以维持正常功能所需的器官形状和大小。虽然BMP最初被鉴定为存在于脱矿骨中的能够诱导异位骨形成的成骨因子，但现在很明显，BMP在胚胎发育期间以及在生物体的成年生活期间执行若干其他功能。许多疾病与BMP或BMP信号通路下游的分子有关。本文综述了现有文献中描述的BMP信号在胚胎发育和成人组织稳态中的作用，提供了一个角度对BMP信号通路的药物干预，以减轻几种疾病的条件。(c)2013 Elsevier Inc. All rights reserved.
Bone morphogenetic protein (BMP) signaling has been implicated in several processes during embryonic development and in adult tissue homeostasis. Maintenance of many organs such as skin, intestinal villi, bones and bone marrow requires continuous regeneration and subsequent differentiation of stem cells in order to maintain organ shape and size necessary for proper functioning. Although BMPs were initially identified as osteogenic factors present in demineralized bone capable of inducing ectopic bone formation, it is now evident that BMPs perform several other functions during embryonic development as well as during the adult life of an organism. Many disorders have been linked to either the BMPs or the molecules functioning downstream of BMP signaling pathway. This review summarizes the existing literature describing the role of BMP signaling during embryonic development and in adult tissue homeostasis to provide a perspective on pharmacological interventions of BMP signaling pathway to mitigate several disease conditions. (c) 2013 Elsevier Inc. All rights reserved.