Pubertally Initiated High-Fat Diet Promotes Mammary Tumorigenesis in Obesity-Prone FVB Mice Similarly to Obesity-Resistant BALB/c Mice.
Pubertally Initiated High-Fat Diet Promotes Mammary Tumorigenesis in Obesity-Prone FVB Mice Similarly to Obesity-Resistant BALB/c Mice.
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DOI：
10.1016/j.tranon.2017.09.004
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发表时间：
2017-12
影响因子：
5
通讯作者：
Schwartz RC
中科院分区：
文献类型：
--
作者：
Zhu Y;Aupperlee MD;Haslam SZ;Schwartz RC
在正常体重但不超重的妇女中，绝经前乳腺癌与动物脂肪消耗增加有关。我们之前在肥胖抵抗型BALB/c小鼠中发现，在DMBA致癌和trp53缺失移植模型中，高饱和动物脂肪（HFD）的饮食促进了乳腺肿瘤的发生。在BALB/c小鼠中进行了这些观察，这些小鼠的HFD体重增加非常适度，我们确定了HFD对FVB小鼠的影响，FVB小鼠的HFD体重增加明显。三周大的FVB小鼠被喂食低脂饮食或HFD，受到7,12-二甲基苯[a]蒽诱导的致癌作用。与BALB/c小鼠一样，HFD促进了乳腺肿瘤的发生。肿瘤的发展很大程度上发生在小鼠变得肥胖之前，这表明动物源性HFD而不是导致肥胖在肿瘤促进中起作用。同样与BALB/c小鼠相似，hfd喂养的FVB小鼠中存在大量早期发生的乳腺腺鳞状肿瘤。HFD小鼠肿瘤中M2巨噬细胞也增加。在肿瘤发生之前，HFD加速了正常乳腺的发育，增加了乳腺M2巨噬细胞，与BALB/c小鼠相似。因此，青春期启动的HFD对致癌乳腺癌的促进作用在很大程度上与体重增加无关。与BALB/c小鼠一样，HFD促进腺鳞癌的发生，提示早期HFD在促进这种三阴性乳腺癌亚型中的作用。M2巨噬细胞募集在两种小鼠品系中都是常见的。我们推测，HFD对免疫功能的类似影响可能有助于流行病学发现，年轻，绝经前，正常体重的女性食用高饱和动物脂肪的饮食，乳腺癌风险增加。
Premenopausal breast cancer is associated with increased animal fat consumption among normal-weight but not overweight women. Our previous findings in obesity-resistant BALB/c mice showed that a diet high in saturated animal fat (HFD) promotes mammary tumorigenesis in both DMBA carcinogenesis and Trp53-null transplant models. Having made these observations in BALB/c mice, which have very modest HFD weight gain, we determined the effects of HFD in FVB mice, which gain significant weight on HFD. Three-week-old FVB mice fed a low-fat diet or HFD were subjected to 7,12-dimethylbenz[a]anthracene-induced carcinogenesis. Like BALB/c mice, HFD promoted mammary tumorigenesis. Development of tumors largely occurred prior to mice becoming obese, indicating the role of animal-derived HFD rather than resulting obesity in tumor promotion. Also similar to BALB/c mice, early-occurring adenosquamous mammary tumors were abundant among HFD-fed FVB mice. Tumors from HFD mice also had increased intra-tumor M2 macrophages. Prior to tumor development, HFD accelerated normal mammary gland development and increased mammary M2 macrophages, similarly to BALB/c mice. The promotional effects of puberty-initiated HFD on carcinogen-induced mammary cancer are thus largely weight gain-independent. Like BALB/c mice, HFD promoted adenosquamous tumors, suggesting a role for early age HFD in promoting this subtype of triple negative mammary cancer. M2 macrophage recruitment was common to both mouse strains. We speculate that a similar effect of HFD on immune function may contribute to epidemiological findings of increased breast cancer risk in young, premenopausal, normal-weight women who consume a diet high in saturated animal fat.
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影响因子：
4.8
作者：
Aupperlee, MD;Smith, KT;Haslam, SZ
通讯作者：
Haslam, SZ
影响因子：
8.2
作者：
Montgomery, M. K.;Hallahan, N. L.;Turner, N.
通讯作者：
Turner, N.
DOI：
10.1152/ajpendo.90368.2008
发表时间：
2009-01-01
影响因子：
5.1
作者：
La Merrill, Michele;Baston, David S.;Threadgill, David W.
通讯作者：
Threadgill, David W.
DOI：
10.1007/bf00918341
发表时间：
1976-01-01
期刊：
TCA (Tissue Culture Association) Manual
影响因子：
--
作者：
BANERJEE M R;WOOD B G;CRUMP L R
通讯作者：
CRUMP L R
影响因子：
--
作者：
Zhu Y;Aupperlee MD;Zhao Y;Tan YS;Kirk EL;Sun X;Troester MA;Schwartz RC;Haslam SZ
通讯作者：
Haslam SZ