Selenium and viral virulence
Selenium and viral virulence
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DOI：
10.1258/0007142991902592
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发表时间：
1999-01-01
影响因子：
6.7
通讯作者：
Beck, MA
中科院分区：
文献类型：
--
作者：
Levander, OA;Beck, MA
柯萨奇病毒引起的心肌炎的小鼠模型被用于研究病毒毒力的营养决定因素。这种方法是由中国进行的研究提出的，该研究表明，喂食由来自克山病地区的低硒成分组成的饮食的小鼠在感染科萨基B-4病毒时，比喂食相同饮食但通过食管插管补充硒的感染小鼠遭受更广泛的心脏损伤。在我们的小鼠中，硒缺乏增加了柯萨奇病毒B-3（CVB 3/20）的已经强毒株的毒力，并且还允许非强毒株（CVB 3/0）向毒力的转化。CVB 3/0的这种转化伴随着病毒基因组的变化，以更接近地匹配强毒病毒CVB 3/20。据作者所知，这是第一份关于宿主营养影响入侵病原体遗传组成的报告。营养学家可能需要考虑这种增加病毒毒力的机制，以便更好地了解饮食/感染关系。
A mouse model of coxsackievirus-induced myocarditis is being used to investigate nutritional determinants of viral virulence. This approach was suggested by research carried out in China which showed that mice fed diets composed of low selenium ingredients from a Keshan disease area suffered more extensive heart damage when infected with a coxsackie B-4 virus than infected mice fed the same diet but supplemented with selenium by esophageal intubation. Selenium deficiency in our mice increased the virulence of an already virulent strain of coxsackievirus B-3 (CVB3/20) and also allowed conversion of a non-virulent strain (CVB3/0) to virulence. Such conversion of CVB3/0 was accompanied by a change in the viral genome to more closely match that of the virulent virus, CVB3/20. As far as the authors are aware, this is the first report of host nutrition influencing the genetic make-up of an invading pathogen. Nutritionists may need to consider this mechanism of increased viral virulence in order to gain a better understanding of diet/infection relationships.