Prevention of acute adriamycin cardiotoxicity by dantrolene in rats
Prevention of acute adriamycin cardiotoxicity by dantrolene in rats
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DOI：
10.1191/0960327104ht443oa
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发表时间：
2004-05-01
影响因子：
2.8
通讯作者：
Bakan, E
中科院分区：
文献类型：
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作者：
Büyükokuroglu, ME;Taysi, S;Bakan, E
丹曲林对急性阿霉素（ADR，20 mg/kg，i. p.）已被检查。给药后48 h，检测血清肌酸激酶同工酶（CK-MB）、乳酸脱氢酶（LDH）、天门冬氨酸氨基转移酶（AST）活性及心肌组织丙二醛（MDA）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）含量。在注射ADR前30 min腹腔注射丹曲林，可明显减轻心肌过氧化损伤，降低血清CK-MB、LDH和AST。然而，丹曲林给药获得的保护作用并不完全，也没有达到对照组的保护作用。丹曲林，在5毫克/公斤，是有用的，以获得显着的保护作用，而更高的丹曲林剂量水平（10毫克/公斤）的保护效果是弱的或不存在。这些结果表明，至少部分地，由于抗氧化特性，丹曲林可以提供一个显着的保护作用，对急性ADR诱导的心脏毒性。
Possible preventive effect of dantrolene against the peroxidative damage in rat heart which was induced by the administration of an acute dose of adriamycin (ADR, 20 mg/kg, i.p.) has been examined. Forty-eight hours after ADR administration, biochemical changes including the activities of serum creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) and the levels of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in heart tissue were measured. Pretreatment of rats with dantrolene, given i.p. 30 min prior to ADR injection, substantially reduced the peroxidative damage in the myocardium, and markedly lowered the serum CK-MB, LDH and AST. The protective effects obtained by dantrolene administration, however, were not complete and did not reach those of the control group. Dantrolene, at 5 mg/kg, was useful to obtain significant protective effects, while the protector effect of higher dantrolene dosing level (10 mg/kg) was weak or absent. These results suggest that, at least in part, due to antioxidative properties, dantrolene may provide a significant protective effect against acute ADR-induced cardiotoxicity.