Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design

Time-resolved single photon spectroscopy through a single optical fibre for miniaturised medical probe design
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通过单光纤的时间分辨单光子光谱,用于小型化医疗探头设计

DOI:
10.1117/12.2307334
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发表时间:
2018
期刊:
--
影响因子:
--
通讯作者:
Tanner M
Tanner M
中科院分区:
--
文献类型:
--
作者:
Tanner M

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我们提出了一种光谱系统和光纤探头,能够充分利用背景荧光和本征光纤拉曼的弱拉曼信号的时间演化和光谱信息。该系统由单根多模光纤和 CMOS 单光子雪崩二极管 (SPAD) 线路传感器组成,能够同时解析 256 个像素的光子到达时间并对其进行直方图绘制,与非时间分辨测量模式相比,可提供更好的背景信号。该系统的功能针对环己烷等内在拉曼标准品以及利用表面增强拉曼散射 (SERS) 的功能化金纳米壳进行 pH 传感进行测试。纳米壳采用 pH 响应型 4-巯基苯甲酸 (MBA) 进行功能化,能够以低激发功率 (< 1 mW) 和短采集时间 (10 s) 演示宽范围 pH 传感,实现 ± 0.07 pH 单位的测量精度。
We present a spectroscopic system and an optical fibre probe which enable the full exploitation of the temporal evolution and spectral information of a weak Raman signal against background fluorescence and intrinsic fibre Raman. The system consists of a single multimode fibre and a CMOS single-photon avalanche diode (SPAD) line sensor capable of resolving and histogramming the arrival times of photons for 256 pixels simultaneously, offering improved signal to background compared to a non-time resolved measurement modality. The capabilities of the system are tested for intrinsic Raman standards such as cyclohexane and for pH sensing with functionalised gold nanoshells exploiting surface enhanced Raman scattering (SERS). The nanoshells are functionalised with the pH responsive 4-mercaptobenzoic acid (MBA) enabling demonstration of wide range pH sensing with low excitation power (< 1 mW) and short acquisition times (10 s), achieving a measurement precision of ± 0.07 pH units.
16.5 giga events/s 1024 × 8 SPAD 线传感器,具有每像素可缩放 50ps-6.4ns/bin 直方图 TDC
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