Two structurally distinct and independently regulated idiotypic families associated with the A/J response to azophenylarsonate
Two structurally distinct and independently regulated idiotypic families associated with the A/J response to azophenylarsonate
复制标题
两个结构不同且独立调控的独特型家族与偶氮苯胂酸的 A/J 反应相关
DOI：
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发表时间：
1981
影响因子：
5.4
通讯作者：
M. Gefter
中科院分区：
文献类型：
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作者：
A. Marshak‐Rothstein;M. N. Margolies;J. D. Benedetto;M. Gefter
At least two distinct subpopulations of A/J anti‐azophenylarsonate (Ars) antibodies can be defined on the basis of serological cross‐reactivity and sequence homology of heavy and light chains. The most frequently occurring idiotype family, IdCR, was initially identified by a rabbit antiserum and is present only in A/J mice. Examination of several randomly selected hybridoma proteins which failed to express IdCR‐associated determinants revealed a second set of closely related molecules. The second idiotype family, Id36–60, is recognized by a rabbit antiserum prepared against the hybridoma protein 36–60. It is present in practically all A/J and BALB/c, but not B10.A Ars immune sera. On average, A/J immune sera contain approximately one‐fifth as much Id36–60 as IdCR.
与表达交叉反应独特型的杂交瘤蛋白相关的独特决定因素：个体免疫血清中的频率。
DOI：
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发表时间：
1980
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Marshak-Rothstein,A;Benedetto,JD;Kirsch,RL;Gefter,ML
通讯作者：
Gefter,ML