Wnt Signaling in Neuromuscular Junction Development
Wnt Signaling in Neuromuscular Junction Development
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DOI：
10.1101/cshperspect.a008045
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发表时间：
2012-06-01
影响因子：
7.2
通讯作者：
Budnik, Vivian
中科院分区：
文献类型：
--
作者：
Koles, Kate;Budnik, Vivian
Wnt蛋白以其在细胞模式中的重要作用而闻名，因为它们是迄今为止研究过的所有动物物种的胚胎发育所必需的。除了调节细胞命运外，Wnt蛋白在神经系统发育和功能中的作用越来越受到重视。新的研究表明，在脊椎动物和无脊椎动物神经肌肉连接的形成过程中，多种正向和负向的Wnt信号通路同时发生。尽管一些wnt对NMJs的形成至关重要，但其他wnt似乎作为多种信号通路的一部分发挥更大的调节作用。在这里，我们回顾了来自脊椎动物和无脊椎动物模型系统的关于NMJ中wnt功能的最新发现。
Wnt proteins are best known for their profound roles in cell patterning, because they are required for the embryonic development of all animal species studied to date. Besides regulating cell fate, Wnt proteins are gaining increasing recognition for their roles in nervous system development and function. New studies indicate that multiple positive and negative Wnt signaling pathways take place simultaneously during the formation of vertebrate and invertebrate neuromuscular junctions. Although some Wnts are essential for the formation of NMJs, others appear to play a more modulatory role as part of multiple signaling pathways. Here we review the most recent findings regarding the function of Wnts at the NMJ from both vertebrate and invertebrate model systems.