Cell migration in the normal and pathological postnatal mammalian brain.
Cell migration in the normal and pathological postnatal mammalian brain.
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DOI：
10.1016/j.pneurobio.2009.02.001
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发表时间：
2009-05
影响因子：
6.7
通讯作者：
Goldman JE
中科院分区：
文献类型：
--
作者：
Cayre M;Canoll P;Goldman JE
在发育中的大脑中，细胞迁移是结构组织的关键过程，因此受到高度调控，以允许正确形成复杂的网络、连接神经元和神经胶质细胞。在出生后早期的大脑中，星形胶质细胞和少突胶质细胞祖细胞的产生和迁移等晚期发育过程仍然发生。尽管大脑在出生几周后就完全形成和结构化，但它在整个生命过程中保持一定程度的可塑性，包括轴突重塑、突触发生，以及神经细胞的诞生、迁移和整合。室下区（SVZ）和海马齿状回（DG）是成人大脑中两个主要的神经源性生态位。神经干细胞驻留在这些结构中，并产生祖细胞，这些祖细胞迁移到它们的最终位置：分别是 DG 的嗅球和颗粒细胞层。本综述的目的是综合有关成熟大脑中细胞迁移的组织、调节和功能的不断增加的信息。在正常大脑中，参与细胞-细胞或细胞-基质相互作用的蛋白质与充当化学引诱剂或化学排斥剂的分泌蛋白一起在神经祖细胞迁移的调节中发挥关键作用。此外，最近的数据表明，神经胶质瘤是由神经干细胞或祖细胞的转化产生的，并且神经胶质瘤细胞浸润概括了神经胶质祖细胞迁移的关键方面。因此，我们将在祖细胞迁移的背景下考虑神经胶质瘤的迁移。最后，许多观察结果表明，脑损伤和神经系统疾病会触发神经干/祖细胞激活并向改变的结构迁移。参与这种细胞迁移/招募的因素才刚刚开始被了解。长期以来，炎症一直被认为对大脑修复具有彻底的灾难性影响，现在人们知道，炎症可以通过调节生长因子信号传导和分泌多种趋化细胞因子，对干细胞/祖细胞的募集产生一些积极影响。这些知识对于开发新的治疗策略至关重要。这些策略之一可能包括增加内源祖细胞的动员，这些祖细胞可以替代丢失的细胞并改善功能恢复。
In the developing brain, cell migration is a crucial process for structural organization, and is therefore highly regulated to allow the correct formation of complex networks, wiring neurons, and glia. In the early postnatal brain, late developmental processes such as the production and migration of astrocyte and oligodendrocyte progenitors still occur. Although the brain is completely formed and structured few weeks after birth, it maintains a degree of plasticity throughout life, including axonal remodeling, synaptogenesis, but also neural cell birth, migration and integration. The subventricular zone (SVZ) and the dentate gyrus of the hippocampus (DG) are the two main neurogenic niches in the adult brain. Neural stem cells reside in these structures and produce progenitors that migrate toward their ultimate location: the olfactory bulb and granular cell layer of the DG respectively. The aim of this review is to synthesize the increasing information concerning the organization, regulation and function of cell migration in a mature brain. In a normal brain, protein involved in cell-cell or cell-matrix interactions together with secreted proteins acting as chemoattractant or chemorepellant play key roles in the regulation of neural progenitor cell migration. In addition, recent data suggest that gliomas arise from the transformation of neural stem cells or progenitor cells and that glioma cell infiltration recapitulates key aspects of glial progenitor migration. Thus, we will consider glioma migration in the context of progenitor migration. Finally, many observations show that brain lesions and neurological diseases trigger neural stem/progenitor cell activation and migration towards altered structures. The factors involved in such cell migration/recruitment are just beginning to be understood. Inflammation which has long been considered as thoroughly disastrous for brain repair is now known to produce some positive effects on stem/progenitor cell recruitment via the regulation of growth factor signaling and the secretion of a number of chemoattractant cytokines. This knowledge is crucial for the development of new therapeutic strategies. One of these strategies could consist in increasing the mobilization of endogenous progenitor cells that could replace lost cells and improve functional recovery.
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影响因子：
3
作者：
AICARDI, J
通讯作者：
AICARDI, J
DOI：
10.1073/pnas.0611391104
发表时间：
2007-05-15
影响因子：
11.1
作者：
Andrade, Nuno;Komnenovic, Vukoslav;Nimpf, Johannes
通讯作者：
Nimpf, Johannes
影响因子：
5.3
作者：
Belmadani, A;Tran, PB;Miller, RJ
通讯作者：
Miller, RJ
影响因子：
5.3
作者：
Assanah, Marcela;Lochhead, Richard;Canoll, Peter
通讯作者：
Canoll, Peter
影响因子：
5.3
作者：
Balordi, Francesca;Fishell, Gord
通讯作者：
Fishell, Gord