The progesterone challenge:: steroid hormone changes following a simulated territorial intrusion in female Peromyscus californicus
The progesterone challenge:: steroid hormone changes following a simulated territorial intrusion in female Peromyscus californicus
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DOI：
10.1016/s0018-506x(03)00128-4
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发表时间：
2003-09-01
影响因子：
3.5
通讯作者：
Marler, CA
中科院分区：
文献类型：
--
作者：
Davis, ES;Marler, CA
越来越多的证据表明，男性雄激素，特别是睾酮的快速但短暂的增加。(T)在一个单一的社会遭遇，如领土入侵发生在广泛的脊椎动物类群。然而，这种现象，通常被称为挑战假说，很少在女性中进行调查。此外，在研究雄性攻击效应时，研究人员很少研究其他对攻击性表达很重要的激素，如孕酮（P-4）和雌二醇（E-2）。我们进行了10分钟的侵略试验，使用居民入侵者的范例骑自行车的女性加州小鼠，Peromyscus californicus，一个物种，其中两性显示领土行为。通过比较试验雌性与对照雌性的激素水平，我们发现P-4和P-4/T比值降低，但T、E-2、皮质酮、E-2/P-4或E-2/T没有变化。有趣的是，这些激素的变化甚至在居民对入侵者没有攻击性的情况下也能观察到，这表明提示激素变化的刺激仅仅是入侵者的存在，而不是居民表现出的攻击性。一般来说，T与攻击性呈正相关，而P-4抑制男性和非母性女性的攻击性。因此，降低P-4/T的比例后，遇到可能会增加未来的侵略女性。这些结果表明，女性可能会使用不同的激素机制比男性调解侵略的挑战情况。(C)2003年爱思唯尔公司All rights reserved.
There is a growing body of evidence that the rapid but transient increase in male androgens, particularly testosterone.(T), following a single social encounter such as a territorial intrusion occurs in a wide array of vertebrate taxa. Yet, this phenomenon, often called the Challenge Hypothesis, has rarely been investigated in females. Moreover, when studying male challenge effects, researchers have rarely investigated other hormones that can be important to the expression of aggression, such as progesterone (P-4) and estradiol (E-2). We conducted 10-min aggression trials using the resident-intruder paradigm in cycling female California mice, Peromyscus californicus, a species in which both sexes show territorial behavior. By comparing the hormone levels of test females to control females, we found a decrease in P-4 and the P-4/T ratio, but no change in T, E-2, corticosterone, E-2/P-4, or E-2/T. Interestingly, these hormone changes were observed even when the resident was not aggressive toward the intruder, suggesting that the stimulus cueing the hormone changes was the mere presence of the intruder and not the amount of aggression displayed by the resident. Generally, T has a positive relationship with aggression, whereas P-4 inhibits male and nonmaternal female aggression. Thus, decreasing the P-4/T ratio following an encounter may serve to increase future aggression in females. These results suggest that females may use different hormonal mechanisms than do males to mediate aggression in a challenge situation. (C) 2003 Elsevier Inc. All rights reserved.