Commentary: How Do Microglia Regulate Neural Circuit Connectivity and Activity in the Adult Brain?
Commentary: How Do Microglia Regulate Neural Circuit Connectivity and Activity in the Adult Brain?
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DOI：
10.1177/26331055211071124
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发表时间：
2022
影响因子：
3.6
通讯作者：
Xu X
中科院分区：
文献类型：
--
作者：
Liu YJ;Green KN;Holmes TC;Xu X
小胶质细胞是中枢神经系统的主要免疫细胞。最近的研究表明，小胶质细胞也是必要的适当的大脑发育，通过突触修剪和重塑在生命早期的发展。但是，小胶质细胞是否以及如何调节成人大脑中的突触连接的问题仍然是开放的。我们最近发表的研究为小胶质细胞在成年小鼠大脑中的功能作用提供了新的见解。我们发现，慢性消耗小胶质细胞通过CSF 1R抑制剂在成年小鼠的视觉皮层诱导神经元周围网络的显着增加，并增强兴奋性神经元和小白蛋白中间神经元的神经活动。这些发现强调了通过操纵小胶质细胞来增强成人神经可塑性的新的潜在治疗途径。
Microglia are the primary immune cells in CNS. Recent work shows that microglia are also essential for proper brain development through synaptic pruning and remodeling during early life development. But the question of whether and how microglia regulate synaptic connectivity in the adult brain remains open. Our recently published study provides new insights into the functional roles of microglia in the adult mouse brain. We find that chronic depletion of microglia via CSF1R inhibitors in the visual cortex in adult mice induces a dramatic increase in perineuronal nets, and enhances neural activities of both excitatory neurons and parvalbumin interneurons. These findings highlight new potential therapeutic avenues to enhance adult neural plasticity by manipulating microglia.
影响因子：
16.6
作者：
Baohan, Amy;Ikrar, Taruna;Tring, Elaine;Xu, Xiangmin;Trachtenberg, Joshua T.
通讯作者：
Trachtenberg, Joshua T.