ELEVATION OF AUDITORY-THRESHOLDS BY SPONTANEOUS COCHLEAR OSCILLATIONS
ELEVATION OF AUDITORY-THRESHOLDS BY SPONTANEOUS COCHLEAR OSCILLATIONS
复制标题
DOI：
10.1038/375585a0
复制
发表时间：
1995-06-15
期刊：
影响因子：
64.8
通讯作者：
QIU, CX
中科院分区：
文献类型：
--
作者：
POWERS, NL;SALVI, RJ;QIU, CX
内耳有时作为一个强大的声音发生器，连续广播声音（自发耳声发射），这些声音可以足够强烈，可以被站在附近的其他人听到（1-4）。奇怪的是，大多数人都没有意识到在他们的耳朵里产生的声音，两个假设可以解释这个悖论：（1）自发发射可能不会被传输到中枢神经系统;或者（2）自发发射产生连续的，高速率的神经活动，就像自发活动的自然模式一样，被中枢神经系统忽略。在这里，我们证明，高强度的自发耳声发射可以大力激活哺乳动物（龙猫）的听觉神经纤维。这种“内部生物噪声”会产生一种“线路忙碌”信号，显著降低神经元对声音的反应能力，导致与感觉细胞损伤完全不同的听力损失（1，4）。
THE inner ear sometimes acts as a robust sound generator, continuously broadcasting sounds (spontaneous otoacoustic emissions) which can be intense enough to be heard by other individuals standing nearby(1-4). Paradoxically, most individuals are unaware of the sounds generated within their ears, Two hypotheses could explain this paradox: (1) the spontaneous emissions may not be transmitted to the central nervous system; or (2) the spontaneous emission produces a continuous, high rate of neural activity, which, like the natural pattern of spontaneous activity, is ignored by the central nervous system. Here we demonstrate that high-intensity spontaneous otoacoustic emissions can vigorously activate auditory nerve fibres in mammals (Chinchilla laniger). This 'internal biological noise' creates a 'line busy' signal that significantly degrades a neuron's ability to respond to sound and results in a hearing loss completely different from that caused by damage to sensory cells(1,4).