Association of high pulse pressure with proteinuria in subjects with diabetes, prediabetes, or normal glucose tolerance in a large Japanese general population sample.
Association of high pulse pressure with proteinuria in subjects with diabetes, prediabetes, or normal glucose tolerance in a large Japanese general population sample.
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在糖尿病，前糖尿病前期或正常葡萄糖耐受性的受试者中，高脉压与蛋白尿的缔合在大型日本总体样本中。
DOI：
10.2337/dc11-2245
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发表时间：
2012-06
期刊：
影响因子：
16.2
通讯作者：
Watanabe T
中科院分区：
文献类型：
--
作者：
Yano Y;Sato Y;Fujimoto S;Konta T;Iseki K;Moriyama T;Yamagata K;Tsuruya K;Yoshida H;Asahi K;Kurahashi I;Ohashi Y;Watanabe T
旨在检查糖尿病、糖尿病前期或糖耐量正常的受试者中，高脉压和蛋白尿之间的关联是否存在差异，独立于其他血压 (BP) 指数，如收缩压或舒张压。我们使用包含 228,778 名 20 岁以上日本人（平均 63.2 岁；39.3% 男性；没有人患有心血管疾病）的全国健康体检数据库，分别研究了糖尿病受试者中高脉压（定义为脉压最高五分位数（≥63 mmHg，n = 40,511））和蛋白尿（试纸上≥1+，n = 12,090）之间的关联（n = 27,913）、糖尿病前期（n = 100,214）和正常糖耐量（n = 100,651）。糖尿病、糖尿病前期和糖耐量正常受试者的蛋白尿患病率不同（分别为 11.3%、5.0% 和 3.9%；P < 0.001）。在糖尿病患者中，但在糖尿病前期或糖耐量正常的患者中，高脉压与蛋白尿相关，独立于显着的协变量，包括收缩压（比值比 1.15 [95% CI 1.04–1.28]）或舒张压或平均血压（所有 P < 0.01）。在糖尿病患者中，即使在调整收缩压 (1.07 [1.00–1.13]) 或舒张压或平均血压后（所有 P < 0.05），脉压增加 +1 SD (+13 mmHg) 与蛋白尿相关。在日本普通人群中，糖尿病、糖尿病前期和糖耐量正常的受试者中，高脉压与蛋白尿之间的关联存在显着差异。仅在糖尿病中，高脉压与蛋白尿相关，与收缩压、舒张压或平均血压水平无关。
To examine whether there is a difference in the association between high pulse pressure and proteinuria, independent of other blood pressure (BP) indices, such as systolic or diastolic BP, among subjects with diabetes, prediabetes, or normal glucose tolerance. Using a nationwide health checkup database of 228,778 Japanese aged ≥20 years (mean 63.2 years; 39.3% men; none had pre-existing cardiovascular disease), we examined the association between high pulse pressure, defined as the highest quintile of pulse pressure (≥63 mmHg, n = 40,511), and proteinuria (≥1+ on dipstick, n = 12,090) separately in subjects with diabetes (n = 27,913), prediabetes (n = 100,214), and normal glucose tolerance (n = 100,651). The prevalence of proteinuria was different among subjects with diabetes, prediabetes, and normal glucose tolerance (11.3 vs. 5.0 vs. 3.9%, respectively; P < 0.001). In subjects with diabetes, but not those with prediabetes or normal glucose tolerance, high pulse pressure was associated with proteinuria independently of significant covariates, including systolic BP (odds ratio 1.15 [95% CI 1.04–1.28]) or diastolic or mean BP (all P < 0.01). In patients with diabetes, a +1 SD increase of pulse pressure (+13 mmHg) was associated with proteinuria, even after adjustment for systolic BP (1.07 [1.00–1.13]) or diastolic or mean BP (all P < 0.05). Among the Japanese general population, there was a significant difference in the association between high pulse pressure and proteinuria among subjects with diabetes, prediabetes, and normal glucose tolerance. Only in diabetes was high pulse pressure associated with proteinuria independent of systolic, diastolic, or mean BP levels.
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DOI：
10.2215/cjn.04381007
发表时间：
2008-03-01
影响因子：
9.8
作者：
de Jong, Paul E.;van der Velde, Marije;Zoccali, Carmine
通讯作者：
Zoccali, Carmine
影响因子：
13.6
作者：
Briet, Marie;Collin, Cedric;Boutouyrie, Pierre
通讯作者：
Boutouyrie, Pierre
影响因子：
8.3
作者：
Ford, Martin L.;Tomlinson, Laurie A.;Holt, Stephen G.
通讯作者：
Holt, Stephen G.
影响因子：
16.2
作者：
de Zeeuw, Dick;Raz, Itamar
通讯作者：
Raz, Itamar
影响因子：
19.6
作者：
Christensen, PK;Hansen, HP;Parving, HH
通讯作者：
Parving, HH