Reaction-diffusion wave model for self-assembled network formation of poly(dA)•poly(dT) DNA on mica and HOPG surfaces
Reaction-diffusion wave model for self-assembled network formation of poly(dA)•poly(dT) DNA on mica and HOPG surfaces
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DOI：
10.1080/10255842.2012.723701
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发表时间：
2014-04-26
影响因子：
1.6
通讯作者：
Kawano, Satoyuki
中科院分区：
文献类型：
--
作者：
Doi, Kentaro;Toyokita, Yukihiro;Kawano, Satoyuki
脱氧核糖核酸（DNA）是生命的重要分子，因为它包含遗传信息。然而，最近有报道称DNA具有独特的性质，使其适合生物纳米电子应用，例如导电性和自组织的可能性。自组装DNA网络结构已经在几种基底上观察到，但详细的自组装机制尚未确定。本研究从理论和实验两方面研究了DNA的自组装结构。我们开发了一个反应扩散模型，并用它来研究原子力显微镜观察到的图案形成。计算结果定性地复制了DNA分子的网络模式的基础上与表面尺寸和时间尺度的定量协议。该模型可以解释DNA浓度对图案形成的影响。此外，还模拟了云母和高度取向的热解石墨表面的特殊几何图案。
Deoxyribonucleic acid (DNA) is a vital molecule for life since it contains genetic information. However, DNA has recently been reported to have unique properties that make it suitable for bionanoelectronic applications, such as the possibility of electrical conductivity and self-organisation. Self-assembled DNA network structures have been observed on several substrates, but the detailed self-assembly mechanism has yet to be determined. The present study investigates self-assembled structures of DNA both theoretically and experimentally. We developed a reaction-diffusion model and used it to investigate pattern formations observed by atomic force microscopy. The computational results qualitatively replicate the network patterns of DNA molecules based on a quantitative agreement with the surface size and timescale. The model can account for the effect of the DNA concentration on pattern formation. Furthermore, peculiar geometric patterns are simulated for mica and highly oriented pyrolytic graphite surfaces.