Non-coding RNAs in Physiological Cardiac Hypertrophy
Non-coding RNAs in Physiological Cardiac Hypertrophy
复制标题
生理性心脏肥大中的非编码RNA
DOI：
10.1007/978-981-15-1671-9_8
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Xiao, Junjie
中科院分区：
文献类型：
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作者：
Wang, Lijun;Wang, Jiaqi;Xiao, Junjie
非编码RNA(Non-Coding RNA，ncRNA)是一类不作为翻译蛋白模板的RNA。它们参与基因转录、RNA成熟和蛋白质翻译的调节，参与多种生理和生理过程。NcRNAs具有重要的功能，是近年来生物医学研究的热点之一。心肌肥厚分为生理性心肌肥厚和病理性心肌肥厚。与病理性心肌肥大不同，生理性心肌肥厚通常发生在运动、妊娠、出生后正常发育过程中，伴有收缩功能的保存或改善，而无心脏纤维化。在本章中，我们将简要介绍ncRNAs的定义、特征和功能，包括miRNAs、lncRNAs和CircRNAs，并对现有的用于ncRNAs研究的生物信息学在线数据库进行综述。本章将重点介绍生理性心肌肥厚的特点及其发生机制。并对ncRNAs在生理性肥大中的调控机制及最新研究进展进行综述。综上所述，探索生理性心肌肥厚特异性的ncRNA可能是一种独特的研究视角，为心力衰竭和其他心血管疾病的干预提供了新的视角。
Non-coding RNA (ncRNA) is a class of RNAs that are not act as translational protein templates. They are involved in the regulation of gene transcription, RNA maturation and protein translation, participating in a variety of physiological and physiological processes. NcRNAs have important functions, and are recently one of the hotspots in biomedical research. Cardiac hypertrophy is classified into physiological cardiac hypertrophy and pathological cardiac hypertrophy. Different-from pathological cardiac hypertrophy, physiological cardiac hypertrophy usually developed during exercise, pregnancy, normal postnatal growth, accompanied with preservation or improvement of systolic function, while no cardiac fibrosis. In this chapter, we will briefly introduce the definition, characteristics, and functions of ncRNAs, including miRNAs, lncRNAs, and circRNAs, as well as a summary of the existing bioinformatics online databases which commonly used in the study of ncRNAs. Specially, this chapter will be focused on the characteristics and the underlying mechanisms about physiological cardiac hypertrophy. Furthermore, the regulatory mechanism of ncRNAs in physiological hypertrophy and the latest research progress will be summarized. Taken together, exploring physiologic cardiac hypertrophy-specific ncRNAs might be a unique research perspective that provides new point of view for interventions in heart failure and other cardiovascular diseases.