COLLAGEN MATRIX CISPLATIN PREVENTS LOCAL TUMOR-GROWTH AFTER MARGIN-POSITIVE RESECTION
COLLAGEN MATRIX CISPLATIN PREVENTS LOCAL TUMOR-GROWTH AFTER MARGIN-POSITIVE RESECTION
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DOI：
10.1006/jsre.1995.1097
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发表时间：
1995-06-01
影响因子：
2.2
通讯作者：
CURLEY, SA
中科院分区：
文献类型：
--
作者：
DAVIDSON, BS;IZZO, F;CURLEY, SA
肿瘤的范围，有时与其解剖位置相结合，可能会影响外科医生获得清晰切除边缘的能力。切除床中肿瘤的区域性复发经常产生显著的局部发病率，并限制患者的生存时间和生活质量。通过在新西兰白色兔中诱导肾周VX-2肿瘤，随后在腹膜后进行具有大体阳性边缘的单侧肾切除术来创建阳性边缘切除模型。切除床注射新型胶原基质与顺铂（CDDP）和肾上腺素防止了所有治疗动物中的肿瘤复发。相比之下，用单独的CDDP、单独的CDDP和肾上腺素或胶原基质与肾上腺素治疗的对照动物在切除床中具有大体积肿瘤复发。在肾切除术和注射胶原基质、CDDP和肾上腺素或不注射胶原基质的CDDP和肾上腺素后1、4和7天，通过无火焰吸收分光光度法测定切除床组织的铂水平。与单独使用CDDP和肾上腺素相比，使用新型胶原基质实现了显著更高的铂切除床药物水平（P < 0.05）。本研究的结果表明，CDDP和一种独特的胶原基质药物递送载体的肿瘤床治疗产生了长期的高铂切除床水平，并防止局部肿瘤复发。(C)出版社：Academic Press
The extent of a tumor, sometimes combined with its anatomic location, can compromise the surgeon's ability to obtain clear margins of resection. Regional recurrence of a tumor in the resection bed frequently produces significant local morbidity and limits patient survival time and quality of life. A positive margin resection model was created by induction of perinephric VX-2 tumors in New Zealand white rabbits followed by unilateral nephrectomy with grossly positive margins in the retroperitoneum, Resection bed injection of a novel collagen matrix with cisplatin (CDDP) and epinephrine prevented tumor recurrence in all treated animals. In contrast, control animals treated with CDDP alone, CDDP and epinephrine alone, or the collagen matrix with epinephrine had bulky tumor recurrence in the resection bed. Resection bed tissue levels of platinum were determined by flameless absorption spectrophotometry at 1, 4, and 7 days following nephrectomy and injection of the collagen matrix, CDDP, and epinephrine or CDDP and epinephrine without the collagen matrix. Significantly higher resection bed drug levels of platinum were achieved through the use of the novel collagen matrix than through the use of CDDP and epinephrine alone (P < 0.05). The results of this study indicate that tumor bed treatment with CDDP and a unique collagen matrix drug-delivery vehicle produces prolonged high resection bed levels of platinum and prevents local tumor recurrence. (C) 1995 Academic Press, Inc.