Acute hypoxemia and hypercapnia: increase in plasma catecholamines in conscious dogs.
Acute hypoxemia and hypercapnia: increase in plasma catecholamines in conscious dogs.
复制标题
急性低氧血症和高碳酸血症：意识清醒的狗血浆儿茶酚胺增加。
DOI：
10.1152/ajpheart.1983.245.6.h924
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Carey,RM
中科院分区：
文献类型：
--
作者：
RoseJr,CE;Althaus,JA;Kaiser,DL;Miller,ED;Carey,RM
为系统评价急性低氧血症和高碳酸血症酸中毒对交感神经系统的影响，研究了5只未麻醉的杂种狗在急性低氧血症[动脉血氧浓度（PaO2） 33 +/- 2 Torr]、急性高碳酸血症酸中毒[动脉血氧浓度（PaCO2） 53 +/- 1 Torr；pH, 7.19 +/- 0.02]，合并急性低氧血症和高碳酸血症酸中毒（PaO2, 36 +/- 1 Torr; PaCO2, 52 +/- 1 Torr; pH, 7.18 +/- 0.02）。合并急性低氧血症和高碳酸血症酸中毒导致平均动脉压、心输出量和心率升高。此外，合并急性低氧血症和高碳酸酸中毒协同作用，增加循环去甲肾上腺素和肾上腺素。单纯急性低氧血症和单纯急性高碳酸酸中毒可导致平均动脉压、心输出量、心率和循环去甲肾上腺素可逆升高。虽然急性低氧血症时血浆肾上腺素浓度升高，但急性高碳酸酸中毒时循环肾上腺素没有变化。这些数据表明，急性低氧血症和高碳酸酸中毒导致循环儿茶酚胺的协同增加。
To systemically evaluate the effects of acute hypoxemia and hypercapnic acidosis on the sympathetic nervous system, five unanesthetized mongrel dogs were studied during acute hypoxemia [arterial O2 tension (PaO2) 33 +/- 2 Torr], acute hypercapnic acidosis [arterial CO2 tension (PaCO2) 53 +/- 1 Torr; pH, 7.19 +/- 0.02], and combined acute hypoxemia and hypercapnic acidosis (PaO2, 36 +/- 1 Torr; PaCO2, 52 +/- 1 Torr; pH, 7.18 +/- 0.02). Combined acute hypoxemia and hypercapnic acidosis resulted in increased mean arterial pressure, cardiac output, and heart rate. Moreover, combining acute hypoxemia and hypercapnic acidosis acted synergistically to increase circulating norepinephrine and epinephrine. Acute hypoxemia alone and acute hypercapnic acidosis alone resulted in reversible increases in mean arterial pressure, cardiac output, heart rate, and circulating norepinephrine. Although plasma epinephrine concentrations increased during acute hypoxemia, circulating epinephrine was unchanged during acute hypercapnic acidosis. These data indicate that acute hypoxemia and hypercapnic acidosis result in synergistic increase in circulating catecholamines.