ANTICONVULSANT DRUGS AND CANCER A Cohort Study in Patients with Severe Epilepsy
ANTICONVULSANT DRUGS AND CANCER A Cohort Study in Patients with Severe Epilepsy
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抗惊厥药物与癌症 严重癫痫患者的队列研究
DOI：
10.1016/s0140-6736(79)91505-8
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
C. Howland
中科院分区：
文献类型：
--
作者：
S. White;A. Mclean;C. Howland
在1931年至1971年期间，Chalfont癫痫中心收治了2000多名癫痫患者，并对他们进行了抗惊厥药的随访，直至1977年底。考虑到年龄和性别因素，1951年至1977年期间的死亡率大大超过同期英格兰和威尔士一般人口的死亡率。一些过量的死亡可直接归因于癫痫，但自杀和循环系统、呼吸系统和恶性疾病造成的死亡也比预期的要多。除了大脑和中枢神经系统外，没有任何特定部位的肿瘤明显过多。特别的是，没有肝脏肿瘤（只有一个胆囊癌）。这使得喂食苯巴比妥的小鼠产生的肝脏肿瘤不太可能是人类主要风险的指标。
Over 2000 epileptic patients admitted to the Chalfont Centre for Epilepsy between 1931 and 1971 and taking anticonvulsants were followed up to the end of 1977. Mortality between 1951 and 1977 was greatly in excess of that in the general population of England and Wales in that period allowing for age and sex. Some of the excess was directly attributable to epilepsy, but there were also more deaths from suicide and circulatory, respiratory, and malignant disease than would be expected. Apart from the brain and central nervous system, no particular site had a significant excess of tumours. In particular, there were no liver tumours (and only one gallbladder carcinoma). This makes it unlikely that the liver tumours produced on feeding phenobarbitone to mice are indicators of major human risk.