Diversity of rabies virus detected in Inner Mongolia, China, 2019-2021
Diversity of rabies virus detected in Inner Mongolia, China, 2019-2021
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2019-2021年中国内蒙古检测到的狂犬病病毒多样性
DOI：
10.1111/tbed.14451
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发表时间：
2022-01-18
影响因子：
4.3
通讯作者：
Tu, Changchun
中科院分区：
文献类型：
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作者：
Feng, Ye;Wang, Yuyang;Tu, Changchun
狂犬病在中国是一个严重的公共卫生问题，95%以上的人类感染是由狗传播的。作为2019年至2021年在内蒙古自治区开展的例行监测的一部分，在家畜（狗、牲畜）和野生食肉动物（狐狸、獾和一只貉）中发生的95例狂犬病疑似病例中，有80例被确认为狂犬病毒（RABV）阳性。基于全N基因的rabv系统发育分析表明，97.5%（78/80）的病毒株属于世界（草原型）进化支，北极相关（AL2）和亚洲（SEA1）进化支各有1株。数据显示，受感染的狐狸已成为中国狂犬病的主要传播源，仅次于犬类，在我国北部和西北部的动物狂犬病流行中起着举足轻重的作用。最近狐狸狂犬病向其他动物物种的传播对公共卫生构成越来越大的威胁，并强调了动物狂犬病监测的重要性。
Rabies is a serious public health issue in China, with over 95% of human infections transmitted by dogs. As part of a routine surveillance carried out in the Inner Mongolia Autonomous Region (IMAR) between 2019 and 2021, 80 of 95 suspected rabies cases in domestic animals (dogs, livestock) and wild carnivores (foxes, badgers, a raccoon dog) were confirmed as rabies virus (RABV) positive. Phylogenetic analysis of RABVs of the 80 cases based on complete N genes showed that 97.5% (78/80) of the virus strains belonged to the Cosmopolitan (steppe-type) clade, with one in each of Arctic-related (AL2) and Asian (SEA1) clades. The data show that infected foxes have become a major transmission source of rabies in China, second only to dogs, and play a pivotal role in animal rabies epizootics in the north and northwest of the country. The recent spread of fox rabies to other animal species presents an increasing threat to public health and emphasizes the importance of animal rabies surveillance.