ULTRASOUND-PROMOTED SYNTHESIS OF ALPHA-DIFLUOROMETHYLATED CARBOXYLIC-ACIDS
ULTRASOUND-PROMOTED SYNTHESIS OF ALPHA-DIFLUOROMETHYLATED CARBOXYLIC-ACIDS
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DOI：
10.1021/jo00284a047
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发表时间：
1989-11-10
影响因子：
3.6
通讯作者：
WATANABE, S
中科院分区：
文献类型：
--
作者：
KITAZUME, T;OHNOGI, T;WATANABE, S
General Procedure. All commerciallyavailable reagents were used without further purification. Nuclear magnetic resonance (NMR) spectra were recorded at 90 or 200 MHz for 1H NMR and 56.5 MHz for 19F NMR in CDC13. 19F chemical shifts are reported in partsper million (ppm) relativeto trifluoroacetic acid (5 0.00) as an external standard.Preparation of 2-(Difluoromethyl) heptanoic Acid via Fluorinated Benzyl Acrylate,(a) Fluorinated Benzyl Acrylate. To a solution of Bu2LiCu, which was prepared from copper iodide (3.8 g, 20 mmol) and n-butyllithium (20 mmol) in freshly dried diethyl ether (30 mL) at 0 C, was added benzyl 2-(trifluoromethyl) propenate (2.3 g, 10 mmol) by using a syringe,
