Segregation and linkage analysis of a large kindred of unipolar depression.
Segregation and linkage analysis of a large kindred of unipolar depression.
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一大类单相抑郁症的分离和连锁分析。
DOI：
10.1159/000117829
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发表时间：
1981
影响因子：
3.2
通讯作者：
R. Elston
中科院分区：
文献类型：
--
作者：
R. Crowe;K. Namboodiri;H. Ashby;R. Elston
我们研究了一大类单相抑郁症的分离和联系。我们根据单基因模型的最佳拟合程度对亲属进行了亚型分类，发现“明确和可能的抑郁症、酗酒和药物依赖”的聚类给出了最佳拟合。由于这本质上是抑郁症谱系疾病 (DSD) 的定义，因此它被认为是 DSD 的亲属。使用“受影响”的这种定义，遗传模型比环境模型更适合数据，尽管差异在统计上并不显着。使用 30 个遗传标记进行的连锁分析并未表明任何测试基因座存在连锁。最后，没有证据表明 DSD 与 30 种遗传标记中的任何一种之间存在关联。
We studied segregation and linkage in a large kindred of unipolar depression. We subtyped the kindred on the basis of best fit to a single gene model and found that the cluster of "definite and probable depression, alcoholism, and drug dependency" gave the best fit. Since this is essentially the definition of depression spectrum disease (DSD), this was considered to be a DSD kindred. Using this definition of "affected" the genetic model provided a better fit to the data than the environmental model, although the difference was not statistically significant. A linkage analysis using 30 genetic markers did not suggest linkage at any of the loci tested. Finally, there was no evidence for an association between DSD and any of the 30 genetic markers.