Metabolic control quality and free radical activity in diabetic patients.
Metabolic control quality and free radical activity in diabetic patients.
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DOI：
10.1016/0168-8227(95)01043-d
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发表时间：
1995-03
影响因子：
5.1
通讯作者：
B. Wierusz-Wysocka;H. Wysocki;H. Byks;D. Zozulińska;A. Wykrętowicz;M. Kazmierczak
中科院分区：
文献类型：
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作者：
B. Wierusz-Wysocka;H. Wysocki;H. Byks;D. Zozulińska;A. Wykrętowicz;M. Kazmierczak
氧化/还原平衡紊乱在糖尿病微血管病变发病机制中的作用在过去几年中经常被讨论。因此，我们决定评估强化胰岛素治疗对自由基产生的选定指标的影响。检测15例1型和15例2型糖尿病患者强化治疗前后血浆过氧化氢（H2 O2）和血清丙二醛（MDA）水平。所有病例的初始H2 O2和MDA水平均显著高于对照组。治疗2周后，两个估计参数的值均显著降低;但仍高于对照组。我们的研究结果似乎证实了以前的建议之间的关系代谢紊乱和氧化应激的糖尿病患者。
The role of oxidative/reductive balance derangement in the pathogenesis of diabetic microangiopathy has often been discussed in the last few years. Therefore, we decided to evaluate the influence of intensive insulin therapy on selected indicators of free radical production. The levels of plasma hydrogen peroxide (H2O2) and serum malonyldialdehyde (MDA) were estimated in 15 patients with Type 1 and 15 with Type 2 diabetes before and after 2 weeks of intensive treatment. The initial H2O2and MDA levels in all cases were significantly higher than in controls. After 2 weeks of treatment, the values for both estimated parameters were significantly lower; however, they were still higher than in the control group. Our results seem to confirm the previous suggestions concerning the relation between metabolic disturbances and oxidative stress in diabetic patients.