Acute encephalopathy with human parvovirus B19 infection in hereditary spherocytosis.
Acute encephalopathy with human parvovirus B19 infection in hereditary spherocytosis.
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遗传性球形红细胞增多症中人细小病毒 B19 感染引起的急性脑病。
DOI：
10.1097/inf.0b013e3181694fcf
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
R. Hanada
中科院分区：
文献类型：
--
作者：
K. Oshima;A. Kikuchi;S. Mochizuki;T. Arai;T. Oishi;R. Hanada
一名患有遗传性球形红细胞增多症的9岁女童，因人类细小病毒B19（PVB19）感染而发生再生障碍性危象和脑病。在临床过程中，我们通过实时聚合酶链反应跟踪了她血浆和脑脊液中的PVB19 DNA，发现她的脑病症状发生在病毒载量高峰期。PVB19相关性脑病可能是由于PVB19的直接侵袭而发生的。
A 9-year-old girl with hereditary spherocytosis developed aplastic crisis and encephalopathy associated with human parvovirus B19 (PVB19) infection. During the clinical course, we followed PVB19 DNA in her plasma and cerebrospinal fluid by real-time polymerase chain reaction and found that her symptoms of encephalopathy had occurred at the peak viral load. PVB19-associated encephalopathy might occur as a result of direct invasion by PVB19.