Engineering Innovative Interfaces for Point-of-Care Diagnostics.
Engineering Innovative Interfaces for Point-of-Care Diagnostics.
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DOI：
10.1016/j.cocis.2023.101718
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发表时间：
2023-06-08
影响因子：
8.9
通讯作者：
中科院分区：
文献类型：
--
作者：
正在进行的2019冠状病毒病（COVID-19）大流行表明，需要敏感和可靠的工具来诊断和监测疾病。传统的诊断方法依赖于集中的实验室检测，导致等待结果的时间很长，并减少了可以提供的检测次数。即时检测（POCTs）是一组将临床检测方法小型化的技术，可以在临床领域（代替传统检测）和传统临床环境之外运行，从而实现新的检测范式。poct的典型例子是妊娠试验、侧流试验和血糖仪。poct的其他用途包括COVID-19、艾滋病毒和疟疾等疾病的诊断分析，但尽管取得了一些成功，但在充分转化这些成本更低、用途更广的解决方案方面仍存在未解决的挑战。为了克服这些挑战，研究人员利用胶体和界面科学的创新来开发各种临床应用的poct设计。在此，我们综述了横向流动分析、其他基于纸的POCTs、蛋白质微阵列分析、微珠流动分析和核酸扩增分析的最新进展。本文还讨论了集成到未来poct中所需的功能，包括简化样本收集、端到端连接和机器学习。
The ongoing Coronavirus disease 2019 (COVID-19) pandemic illustrates the need for sensitive and reliable tools to diagnose and monitor diseases. Traditional diagnostic approaches rely on centralized laboratory tests that result in long wait times to results and reduce the number of tests that can be given. Point-of-care tests (POCTs) are a group of technologies that miniaturize clinical assays into portable form factors that can be run both in clinical areas ––in place of traditional tests–– and outside of traditional clinical settings ––to enable new testing paradigms. Hallmark examples of POCTs are the pregnancy test lateral flow assay and the blood glucose meter. Other uses for POCTs include diagnostic assays for diseases like COVID-19, HIV, and malaria but despite some successes, there are still unsolved challenges for fully translating these lower cost and more versatile solutions. To overcome these challenges, researchers have exploited innovations in colloid and interface science to develop various designs of POCTs for clinical applications. Herein, we provide a review of recent advancements in lateral flow assays, other paper based POCTs, protein microarray assays, microbead flow assays, and nucleic acid amplification assays. Features that are desirable to integrate into future POCTs, including simplified sample collection, end-to-end connectivity, and machine learning, are also discussed in this review.
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