TGF-alpha expression as a potential biomarker of risk within the normal-appearing colorectal mucosa of patients with and without incident sporadic adenoma.
TGF-alpha expression as a potential biomarker of risk within the normal-appearing colorectal mucosa of patients with and without incident sporadic adenoma.
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DOI：
10.1158/1055-9965.epi-08-0732
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发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
Seabrook ME
中科院分区：
文献类型：
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作者：
Daniel CR;Bostick RM;Flanders WD;Long Q;Fedirko V;Sidelnikov E;Seabrook ME
转化生长因子-α(转化生长因子-α)是一种刺激性生长因子，是表皮生长因子家族的成员，在结直肠癌的发生、发展过程中起中介作用。有限的证据表明，它可以作为结直肠癌风险的生长相关生物标记物。我们用自动免疫组织化学和定量图像分析方法检测了29例患者和31名对照的大肠黏膜活检组织中转化生长因子-α的表达，这些样本来自一项基于结肠镜检查的病例对照研究(n=203)。通过有效问卷对饮食、生活方式和病史进行评估。转化生长因子-α在直肠组织中的表达较对照组高51%(P=0.0 5)，且与结直肠癌的公认危险因素显著相关(非类固醇抗炎药使用者低36%，激素替代治疗妇女低49%，有结直肠癌家族史者高79%)。转化生长因子-α在外观正常的直肠黏膜中的表达有望成为结直肠癌风险的早期、潜在的可改变的生物标志物。
Transforming growth factor-α (TGF-α), a stimulatory growth factor and member of the epidermal growth factor family, is a mediator of oncogenesis and malignant progression in colorectal carcinogenesis. Limited evidence suggests its utility as a growth-related biomarker of risk for colorectal cancer. We measured expression of TGF-α in biopsies of normal-appearing colorectal mucosa using automated immunohistochemistry and quantitative image analysis in a subsample of 29 cases and 31 controls from a colonoscopy-based case-control study (n = 203) of biomarkers of risk for incident sporadic colorectal adenoma. Diet, lifestyle, and medical history were assessed with validated questionnaires. TGF-α expression in the rectum was 51% higher in cases compared with controls (P = 0.05) and statistically significantly associated with accepted risk factors for colorectal neoplasms (36% lower among nonsteroidal anti-inflammatory drug users, 49% lower among women using hormone replacement therapy, 79% higher among persons with a family history of colorectal cancer). TGF-α expression in the normal-appearing rectal mucosa shows promise as an early, potentially modifiable biomarker of risk for colorectal cancer.