Inflammation and peripheral arterial disease: The value of circulating biomarkers (Review)
Inflammation and peripheral arterial disease: The value of circulating biomarkers (Review)
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DOI：
10.3892/ijmm.2014.1657
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发表时间：
2014-04-01
影响因子：
5.4
通讯作者：
Malaponte, Grazia
中科院分区：
文献类型：
--
作者：
Signorelli, Salvatore Santo;Fiore, Valerio;Malaponte, Grazia
外周动脉疾病(PAD)是动脉粥样硬化性血管疾病的一种表现，通常与其他合并症相关，如高血压、糖尿病和血脂异常。越来越多的证据支持炎症在PAD的发生和发展中起重要作用的观点。许多研究已经调查了各种急性期蛋白，特别是C反应蛋白(CRP)与PAD的关系。除CRP外，其他循环标志物如基质金属蛋白酶(MMPs)、选择素和白介素1(IL)-1、IL-2、IL-6、IL-8和IL-10也被认为在PAD的发生发展中起作用。本文就这些循环标志物在PAD中的作用作一综述。目前的数据表明，在PAD患者中适当使用生物标志物可能有助于早期诊断，增强对疾病发展过程的了解，以及随后改进现有治疗方法和开发新的治疗方法。
Peripheral arterial disease (PAD) is a manifestation of atherosclerotic vascular disease and is often associated with other comorbidities, such as hypertension, diabetes and dyslipidemia. An increasing body of evidence supports the notion that inflammation plays an important role in the development and progression of PAD. A number of studies have investigated the association of various acute phase proteins, particularly C-reactive protein (CRP), with PAD. Apart from CRP, other circulating biomarkers, such as matrix metalloproteinases (MMPs), selectins and interleukin (IL)-1, IL-2, IL-6, IL-8 and IL-10 have been considered to play a role in the development of PAD. In this review, the role of these circulating biomarkers in PAD is discussed. Current data indicate that the appropriate use of biomarkers in patients with PAD may contribute to an early diagnosis, an enhanced knowledge of the developmental process of the disease, as well as to the subsequent improvement of current therapies and to the development of new ones.